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Enhanced Intrusion of Exogenous Airborne Fine Particles toward Eyes in Humans and Animals: Where Damaged Blood-Ocular Barrier Plays a Crucial Role.
Qi, Yu; Liu, Xiaoxue; Chen, Yucai; Wu, Yue; Sun, Yu; Liu, Xiaoyu; Bao, Qingdong; Zhang, Jingjing; Yuan, Gongqiang; Wang, Ting; Sun, Xiaolei; Liu, Sijin; Gao, Hua.
Afiliación
  • Qi Y; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
  • Liu X; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Chen Y; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University, Qingdao 266000, China.
  • Wu Y; School of Ophthalmology, Shandong First Medical University & Shandong Academy of Medical Science, Jinan 250000, China.
  • Sun Y; Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China.
  • Liu X; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
  • Bao Q; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Zhang J; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
  • Yuan G; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Wang T; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University, Qingdao 266000, China.
  • Sun X; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University, Qingdao 266000, China.
  • Liu S; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University, Qingdao 266000, China.
  • Gao H; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University, Qingdao 266000, China.
Environ Sci Technol ; 58(31): 13636-13647, 2024 Aug 06.
Article en En | MEDLINE | ID: mdl-38961559
ABSTRACT
Emerging data suggest a close correlation between ambient fine particle (AFP) exposure and eye disorders and pinpoint potential threats of AFPs to eye health in humans. However, the possible passage (including direct intrusion) and the interactions of AFPs with the eye microenvironment in addition to morphological and physiological injuries remain elusive. To this end, the likely transport of AFPs into the eyes via blood-ocular barrier (BOB) in humans and animals was investigated herein. Exogenous particles were recognized inside human eyes with detailed structural and chemical fingerprints. Importantly, comparable AFPs were found in sera with constant structural and chemical fingerprints, hinting at the translocation pathway from blood circulation into the eye. Furthermore, we found that the particle concentrations in human eyes from patients with diabetic retinopathy were much higher than those from patients with no fundus pathological changes (i.e., myopia), indicating that the damaged BOB increased the possibility of particle entrance. Our diseased animal model further corroborated these findings. Collectively, our results offer a new piece of evidence on the intrusion of exogenous particles into human eyes and provide an explanation for AFP-induced eye disorders, with substantially increased risk in susceptible individuals with BOB injuries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Material Particulado Límite: Animals / Humans / Male Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Material Particulado Límite: Animals / Humans / Male Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos