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A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases.
Liang, Zaolan; Lin, Xia; Sun, Lihong; Edwards, Kimberly M; Song, Wenjun; Sun, Hailiang; Xie, Yanmin; Lin, Fangmei; Ling, Shiman; Liang, Tingting; Xiao, Biying; Wang, Jiaqi; Li, Min; Leung, Chin-Yu; Zhu, Huachen; Bhandari, Nisha; Varadarajan, Raghavan; Levine, Min Z; Peiris, Malik; Webster, Robert; Dhanasekaran, Vijaykrishna; Leung, Nancy H L; Cowling, Benjamin J; Webby, Richard J; Ducatez, Mariette; Zanin, Mark; Wong, Sook-San.
Afiliación
  • Liang Z; HKU-Pasteur Research Pole, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Lin X; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Sun L; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
  • Edwards KM; HKU-Pasteur Research Pole, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Song W; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Sun H; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
  • Xie Y; Guangzhou Institute for Respiratory Health and First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Lin F; HKU-Pasteur Research Pole, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Ling S; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Liang T; Guangzhou National Laboratory, No. 9 XingDaoHuanBei Road, Guangzhou International Bio Island, Guangzhou, 510005, Guangdong Province, China.
  • Xiao B; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
  • Wang J; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Li M; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
  • Leung CY; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
  • Zhu H; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
  • Bhandari N; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
  • Varadarajan R; State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
  • Levine MZ; HKU-Pasteur Research Pole, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Peiris M; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Webster R; HKU-Pasteur Research Pole, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Dhanasekaran V; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Leung NHL; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, China.
  • Cowling BJ; Joint Institute of Virology (Shantou University and The University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou, P. R. China.
  • Webby RJ; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, India.
  • Ducatez M; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, India.
  • Zanin M; US Center for Disease Control and Prevention, Atlanta, GA, USA.
  • Wong SS; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Nat Commun ; 15(1): 5593, 2024 Jul 03.
Article en En | MEDLINE | ID: mdl-38961067
ABSTRACT
Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pandemic, we investigate the reactivity of N2 antibodies against A(H9N2) AIVs. Serosurvey of healthy individuals reveal the highest rates of AIV N2 antibodies in individuals aged ≥65 years. Exposure to the 1968 pandemic N2, but not recent N2, protected against A(H9N2) AIV challenge in female mice. In some older adults, infection with contemporary A(H3N2) virus could recall cross-reactive AIV NA antibodies, showing discernable human- or avian-NA type reactivity. Individuals born before 1957 have higher anti-AIV N2 titers compared to those born between 1957 and 1968. The anti-AIV N2 antibodies titers correlate with antibody titers to the 1957 N2, suggesting that exposure to the A(H2N2) virus contribute to this reactivity. These findings underscore the critical role of neuraminidase immunity in zoonotic and pandemic influenza risk assessment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacciones Cruzadas / Gripe Humana / Subtipo H3N2 del Virus de la Influenza A / Pandemias / Anticuerpos Antivirales / Neuraminidasa Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacciones Cruzadas / Gripe Humana / Subtipo H3N2 del Virus de la Influenza A / Pandemias / Anticuerpos Antivirales / Neuraminidasa Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido