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Neural dysfunction underlying working memory processing at different stages of the illness course in schizophrenia: a comparative meta-analysis.
Yao, Yuhao; Zhang, Shufang; Wang, Boyao; Lin, Xiaoyong; Zhao, Gaofeng; Deng, Hong; Chen, Ying.
Afiliación
  • Yao Y; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
  • Zhang S; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China.
  • Wang B; Functional & Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
  • Lin X; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Zhao G; West China School of Nursing, Sichuan University, Chengdu, China.
  • Deng H; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
  • Chen Y; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China.
Cereb Cortex ; 34(7)2024 Jul 03.
Article en En | MEDLINE | ID: mdl-38960703
ABSTRACT
Schizophrenia, as a chronic and persistent disorder, exhibits working memory deficits across various stages of the disorder, yet the neural mechanisms underlying these deficits remain elusive with inconsistent neuroimaging findings. We aimed to compare the brain functional changes of working memory in patients at different stages clinical high risk, first-episode psychosis, and long-term schizophrenia, using meta-analyses of functional magnetic resonance imaging studies. Following a systematic literature search, 56 whole-brain task-based functional magnetic resonance imaging studies (15 for clinical high risk, 16 for first-episode psychosis, and 25 for long-term schizophrenia) were included. The separate and pooled neurofunctional mechanisms among clinical high risk, first-episode psychosis, and long-term schizophrenia were generated by Seed-based d Mapping toolbox. The clinical high risk and first-episode psychosis groups exhibited overlapping hypoactivation in the right inferior parietal lobule, right middle frontal gyrus, and left superior parietal lobule, indicating key lesion sites in the early phase of schizophrenia. Individuals with first-episode psychosis showed lower activation in left inferior parietal lobule than those with long-term schizophrenia, reflecting a possible recovery process or more neural inefficiency. We concluded that SCZ represent as a continuum in the early stage of illness progression, while the neural bases are inversely changed with the development of illness course to long-term course.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Encéfalo / Imagen por Resonancia Magnética / Memoria a Corto Plazo Límite: Humans Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Encéfalo / Imagen por Resonancia Magnética / Memoria a Corto Plazo Límite: Humans Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos