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Effect of ripasudil after trabeculectomy with mitomycin C: a multicentre, randomised, prospective clinical study.
Muhlisah, Aisyah; Hirooka, Kazuyuki; Nurtania, Ariyanie; Onoe, Hiromitsu; Okumichi, Hideaki; Nitta, Eri; Baba, Tetsuya; Tanito, Masaki; Matsuoka, Yotaro; Nakakura, Shunsuke; Kiuchi, Yoshiaki.
Afiliación
  • Muhlisah A; Department of Ophthalmology and Visual Science, Hiroshima University Faculty of Medicine Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan.
  • Hirooka K; Department of Ophthalmology and Visual Science, Hiroshima University Faculty of Medicine Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan khirooka9@gmail.com.
  • Nurtania A; Department of Ophthalmology and Visual Science, Hiroshima University Faculty of Medicine Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan.
  • Onoe H; Hiroshima University Faculty of Medicine Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan.
  • Okumichi H; Ophthalmology, Hiroshima University Faculty of Medicine Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan.
  • Nitta E; Department of Ophthalmology, Kagawa University Faculty of Medicine Graduate School of Medicine, Kita-gun, Kagawa, Japan.
  • Baba T; Department of Ophthalmology, Shirai Eye Hospital, Mitoyo, Japan.
  • Tanito M; Shimane University Faculty of Medicine Graduate School of Medicine Department of Ophthalmology, Izumo, Shimane, Japan.
  • Matsuoka Y; Department of Ophthalmology, Matsue Red Cross Hospital, Matsue, Japan.
  • Nakakura S; Ophthalmology, Saneiekai Tsukazaki Hospital, Himeji, Japan.
  • Kiuchi Y; Ophthalmology, Hiroshima University Faculty of Medicine Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan.
BMJ Open Ophthalmol ; 9(1)2024 Jul 02.
Article en En | MEDLINE | ID: mdl-38960415
ABSTRACT

BACKGROUND:

To investigate if there are improvements in trabeculectomy outcomes supporting filtration bleb formation caused by Rho-associated protein kinase (ROCK) inhibitors.

METHODS:

This prospective, multicentre, randomised, open-label clinical study examined open-angle glaucoma patients who underwent trabeculectomy or trabeculectomy combined with cataract surgery followed by 3-month postoperative ripasudil treatments. After randomly allocating patients to ripasudil-ROCK inhibitor (ripasudil) or without ripasudil (non-ripasudil) groups. Mean intraocular pressure (IOP) changes, success rate, and number of eyedrops were compared for both groups.

RESULTS:

A total of 17 and 15 subjects dropped out in the ripasudil group and non-ripasudil group, respectively. At baseline, the mean IOP was 16.8±5.0 mm Hg in the ripasudil group (38 patients) and 16.2±4.4 in the non-ripasudil group (52 patients). The IOP decreased to 11.4±3.2 mm Hg, 10.9±3.9 mm Hg and 10.6±3.5 mm Hg at 12, 24 and 36 months in the ripasudil group, while it decreased to 11.2±4.1 mm Hg, 10.5±3.1 mm Hg and 10.9±3.2 mm Hg at 12, 24 and 36 months in the non-ripasudil group, respectively. There was a significant decrease in the number of IOP-lowering medications after trabeculectomy in the ripasudil group versus the non-ripasudil group at 24 (p=0.010) and 36 months (p=0.016). There was no statistically significant difference between the groups for the 3-year cumulative probability of success.

CONCLUSION:

Although ripasudil application did not increase the primary trabeculectomy success rate, it did reduce IOP-lowering medications after trabeculectomy with mitomycin C.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonamidas / Trabeculectomía / Glaucoma de Ángulo Abierto / Mitomicina / Presión Intraocular / Isoquinolinas Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMJ Open Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonamidas / Trabeculectomía / Glaucoma de Ángulo Abierto / Mitomicina / Presión Intraocular / Isoquinolinas Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: BMJ Open Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido