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Spatially offset Raman scattering line-mapping as an adaptive tool ensuring accuracy for determination of component concentrations in tablets with different particle sizes.
Cho, Sanghoon; Il Jang, Jin; Min Kim, Hyung; Kim, Jaejin; Chung, Hoeil.
Afiliación
  • Cho S; Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 04763, Republic of Korea.
  • Il Jang J; Department of Chemistry, Kookmin University, 77 Jeongneung-ro, Seoul 02707, Republic of Korea.
  • Min Kim H; Department of Chemistry, Kookmin University, 77 Jeongneung-ro, Seoul 02707, Republic of Korea.
  • Kim J; Mokpo Marine Food-Industry Research Center, Mokpo-si, Jeollanam-do 58621, Republic of Korea. Electronic address: basickjj@mokpoabo.kr.
  • Chung H; Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, Seoul 04763, Republic of Korea. Electronic address: hoeil@hanyang.ac.kr.
Spectrochim Acta A Mol Biomol Spectrosc ; 321: 124751, 2024 Nov 15.
Article en En | MEDLINE | ID: mdl-38959689
ABSTRACT
Spatially offset Raman scattering (SORS) line-mapping was explored as a versatile tool to examine accuracy variations in compositional analyses of tablets with different particle sizes. SORS spectra collected near the laser irradiation were less representative of tablet composition due to the limited spectroscopic sampling volume, while the signal-to-noise (S/N) ratios of corresponding spectra were higher. On the other hand, SORS spectra at longer offset distances were better representative of tablet composition, while their S/N ratios were decreased considerably. Therefore, the use of only a certain portion of sliced (line-mapped) spectra balanced with the sample representation and S/N ratio could be advantageous to enhance accuracy. Moreover, a group of optimal slice spectra is expected to vary when the particle size of the tablet changes since the characteristics of internal photon propagation also would change. For the overall examination, SORS spectra of 30 Anaprox tablets (composed of 4 constituents including naproxen sodium) with 2 particle sizes (88.4 ± 11.8 µm and 118.9 ± 38.8 µm) were analyzed, and the concentrations of three components in these tablets were determined. A total of 6 cases (3 components and 2 particle sizes) were examined. When the average optimal slice spectra were employed in each case, the errors were lower compared to those using the average of all slice spectra. The demonstrated scheme was versatile to study the offset distance-dependent accuracy variations according to particle size and target component.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamaño de la Partícula / Espectrometría Raman / Comprimidos Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tamaño de la Partícula / Espectrometría Raman / Comprimidos Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido