Your browser doesn't support javascript.
loading
Do low skeletal muscle bulk and disturbed body fat mass impact tumor recurrence in stage I/II HCC undergoing surgery? An observational cohort study.
Lee, Chao-Wei; Tsai, Hsin-I; Hsu, Hsiao-Mei; Yu, Ming-Chin; Lee, Wei-Chen; Wang, Chih-Chi; Hsieh, Yi-Chung; Lin, Cheng-Yu; Cheng, Mei-Ling; Lo, Chi-Jen; Wang, Ching-Ting; Lin, Yu-Chin.
Afiliación
  • Lee CW; Division of General Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan.
  • Tsai HI; College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
  • Hsu HM; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Guishan, Taoyuan, Taiwan.
  • Yu MC; College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
  • Lee WC; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Guishan, Taoyuan, Taiwan.
  • Wang CC; Department of Anesthesiology, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan.
  • Hsieh YC; Department of Family Medicine, Taipei City Hospital Zhongxiao Branch, Taipei, Taiwan.
  • Lin CY; College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
  • Cheng ML; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Guishan, Taoyuan, Taiwan.
  • Lo CJ; Division of General Surgery, Department of Surgery, New Taipei Municipal Tu-Cheng Hospital (Built and Operated by Chang Gung Medical Foundation), Tu-Cheng, New Taipei City, Taiwan.
  • Wang CT; Division of General Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan.
  • Lin YC; College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
Int J Surg ; 2024 Jul 03.
Article en En | MEDLINE | ID: mdl-38959093
ABSTRACT

INTRODUCTION:

The influence of deranged body composition on stage I/II HCC after surgery remains undetermined. The current study aimed to investigate the impact of low skeletal muscle bulk and disturbed body fat mass on the recurrence outcome of stage I/II HCC patients undergoing liver resection. The associated metabolomic alterations were also assessed.

METHODS:

From 2012 to 2021, stage I and II HCC patients who underwent liver resection at our institute were retrospectively reviewed. Their preoperative body composition including skeletal muscle mass and body fat volume was measured by computed tomography (CT). The recurrence outcome was recorded and analyzed. The preoperative serum was collected and subjected to metabolomic analysis.

RESULTS:

A total of 450 stage I and II HCC patients were included in the current study. Among them, 76% were male and around 60% had HBV infection. After stratified by normal cutoff values obtained from a healthy cohort, 6.4% of stage I/II HCC patients were found to have a low psoas muscle index (PMI), 17.8% a high subcutaneous adipose tissue (SAT) index, and 27.8% a high visceral adipose tissue (VAT) index. Cox regression multivariate analysis further demonstrated that low PMI and high SAT index were independent prognostic factors for time-to-recurrence (TTR) after surgery. Metabolomic analysis discovered that free fatty acid ß-oxidation was enhanced in with low PMI or high SAT index.

CONCLUSION:

The current study demonstrated that reduced psoas muscle mass may impair while elevated SAT may prolong the TTR of stage I/II HCC patients undergoing liver resections. VAT, on the other hand, was not associated with recurrence outcome after surgery. Further studies are warranted to validate our findings.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Surg Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Surg Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos