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Lesion characteristics are associated with bowel, bladder, and overall independence following cervical spinal cord injury.
Thornton, Wesley A; Smulligan, Katherine; Weber, Kenneth A; Tefertiller, Candace; Mañago, Mark; Sevigny, Mitch; Wiley, Laura; Stevens-Lapsley, Jennifer; Smith, Andrew C.
Afiliación
  • Thornton WA; Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Smulligan K; Craig Hospital, Englewood, Colorado, USA.
  • Weber KA; Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Tefertiller C; Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
  • Mañago M; Craig Hospital, Englewood, Colorado, USA.
  • Sevigny M; Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Wiley L; Craig Hospital, Englewood, Colorado, USA.
  • Stevens-Lapsley J; Department of Biostatistics & Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Smith AC; Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, Colorado, USA.
J Spinal Cord Med ; : 1-9, 2024 Jul 03.
Article en En | MEDLINE | ID: mdl-38958637
ABSTRACT
CONTEXT/

OBJECTIVE:

There is a growing global interest in quantifying spinal cord lesions and spared neural tissue using magnetic resonance imaging (MRI) in individuals with spinal cord injury (SCI). The primary objective of this study was to assess the relationships between spinal cord lesion characteristics assessed on MRI and bowel, bladder, and overall independence following SCI.

DESIGN:

Retrospective, exploratory study.

PARTICIPANTS:

93 individuals with cervical SCI who were enrolled in a local United States Model Systems SCI database from 2010 to 2017.

METHODS:

Clinical and MRI data were obtained for potential participants, and MRIs of eligible participants were analyzed. Explanatory variables, captured on MRIs, included intramedullary lesion length (IMLL), midsagittal ventral tissue bridge width (VTBW), midsagittal dorsal tissue bridge width (DTBW), and axial damage ratio (ADR). OUTCOME

MEASURES:

Bowel and bladder management scale of the Functional Independence Measure (FIM) and FIM total motor score.

RESULTS:

When accounting for all four variables, only ADR was significantly associated with bowel independence (OR = 0.970, 95% CI 0.942-0.997, P = 0.030), and both ADR and IMLL were strongly associated with bladder independence (OR = 0.967, 95% CI 0.936-0.999, P = 0.046 and OR = 0.948, 95% CI 0.919-0.978, P = 0.0007, respectively). 32% of the variation in overall independence scores were explained by all four predictive variables, but only ADR was significantly associated with overall independence after accounting for all other predictive variables (ß = -0.469, 95% CI -0.719, -0.218, P = 0.0004).

CONCLUSIONS:

Our results suggest that the MRI-measured extent of spinal cord lesion may be predictive of bowel, bladder, and overall independence following cervical SCI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Spinal Cord Med Asunto de la revista: NEUROLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Spinal Cord Med Asunto de la revista: NEUROLOGIA / REABILITACAO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido