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Adverse drug reactions, adherence, and virologic outcomes in adult patients on dolutegravir-based antiretroviral therapy at a tertiary hospital, southeast Nigeria.
Ogbonnaya, Lawrence U; Onah, Cosmas K; Azuogu, Benedict N; Akpa, Christian O; Okeke, Kingsley C; Nwachukwu, Violet N; Stephen-Emeya, Adaeze; Asaga, Irene U; Umeokonkwo, Chukwuma D.
Afiliación
  • Ogbonnaya LU; Department of Community Medicine, College of Health Sciences Ebonyi State University Abakaliki Nigeria.
  • Onah CK; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria.
  • Azuogu BN; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria.
  • Akpa CO; Department of Community Medicine, College of Health Sciences Ebonyi State University Abakaliki Nigeria.
  • Okeke KC; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria.
  • Nwachukwu VN; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria.
  • Stephen-Emeya A; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria.
  • Asaga IU; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria.
  • Umeokonkwo CD; Department of Community Medicine, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State Nigeria.
Ghana Med J ; 58(1): 101-108, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38957273
ABSTRACT

Objective:

To assess the adherence, adverse drug reactions (ADR), and virologic outcomes of dolutegravir-based antiretroviral therapy.

Design:

This was a retrospective chart review.

Setting:

A tertiary health facility-based study in Abakaliki, Nigeria.

Participants:

Five hundred and fifteen (515) adult patients on dolutegravir were selected using a Random Number Generator. Demographic and clinical data were extracted from patients' case notes and analysed with IBM-SPSS version-25. Main outcome

measures:

Adherence to dolutegravir, ADRs, virologic outcome, and change in Body Mass Index (BMI) were estimated.

Results:

The mean age of the patients was 45.5±10.8 years; 68.2% of them were females; 97.1% of them had good self-reported adherence. The majority (82.9%) of them reported no ADRs and among those (17.1%) that did, headache (9.7%), body-itching (3.1%), and skin rash (2.7%) dominated. Most achieved viral suppression (94.4%) and did not have detectable viral particles (57.4%). There was a significant increase in the BMI of the patients with a mean weight increase of 0.9kg, a mean BMI increase of 0.3 kg/m2, and a 2.6% increase in the prevalence of overweight and obesity.

Conclusions:

Patients on dolutegravir reported low ADRs, good self-reported adherence, and a high viral suppression rate. However, dolutegravir is associated with weight gain. We recommend widespread use and more population-wide studies to elucidate the dolutegravir-associated weight gain.

Funding:

None declared.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazinas / Piperazinas / Piridonas / Índice de Masa Corporal / Infecciones por VIH / Inhibidores de Integrasa VIH / Cumplimiento de la Medicación / Centros de Atención Terciaria / Compuestos Heterocíclicos con 3 Anillos Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Ghana Med J Año: 2024 Tipo del documento: Article Pais de publicación: Ghana
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazinas / Piperazinas / Piridonas / Índice de Masa Corporal / Infecciones por VIH / Inhibidores de Integrasa VIH / Cumplimiento de la Medicación / Centros de Atención Terciaria / Compuestos Heterocíclicos con 3 Anillos Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Ghana Med J Año: 2024 Tipo del documento: Article Pais de publicación: Ghana