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Obesity is associated with lower levels of negative emotions in polycystic ovary syndrome in clinical and animal studies.
Zhang, Haolin; Ye, Yang; Zhao, Yue; Li, Shi; Jiao, Peijie; Yang, Yang; Jin, Yuxin; Zeng, Lin; Zhang, Hua; Chen, Meishuang; Jiang, Hong; Zhou, Lifei; Li, Jiayi; Li, Dong; Li, Rong.
Afiliación
  • Zhang H; Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing, China.
  • Ye Y; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
  • Zhao Y; Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing, China.
  • Li S; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
  • Jiao P; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
  • Yang Y; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
  • Jin Y; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
  • Zeng L; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
  • Zhang H; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
  • Chen M; Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing, China.
  • Jiang H; Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing, China.
  • Zhou L; Research Centre of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
  • Li J; Research Centre of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
  • Li D; State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
  • Li R; National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Ann Med ; 56(1): 2373199, 2024 Dec.
Article en En | MEDLINE | ID: mdl-38956857
ABSTRACT

BACKGROUND:

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in women of reproductive age. It is frequently comorbid with obesity and negative emotions. Currently, there are few reports on the relationship between obesity and negative emotions in patients with PCOS. Here we performed both basic and clinical studies to study the relationship between obesity and negative emotions in PCOS.

METHODS:

We performed a cross-sectional study including 608 patients with PCOS and 184 healthy participants to assess the mental health status of people with different body mass indices (BMI). Self-rated anxiety, depression, and perceived stress scales were used for subjective mood evaluations. Rat PCOS models fed 45 and 60% high-fat diets were used to confirm the results of the clinical study. Elevated plus maze and open field tests were used to assess anxiety- and depression-like behaviors in rats.

RESULTS:

We observed overweight/obesity, increased depression, anxiety, and perceived stress in women with PCOS, and found that anxiety and depression were negatively correlated with BMI in patients with severe obesity and PCOS. Similar results were confirmed in the animal study; the elevated plus maze test and open field test demonstrated that only 60% of high fat diet-induced obesity partly reversed anxiety- and depression-like behaviors in PCOS rats. A high-fat diet also modulated rat hypothalamic and hippocampal luteinizing hormone and testosterone levels.

CONCLUSION:

These results reveal a potential relationship between obesity and negative emotions in PCOS and prompt further investigation. The interactions between various symptoms of PCOS may be targeted to improve the overall well-being of patients.
Obesity was negatively correlated with negative emotions in patients with PCOS.Obesity may affect the downregulation of LH and testosterone and participate in the regulation of emotions.Increased BMI may be beneficial for patients with PCOS in terms of the psychological aspects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Síndrome del Ovario Poliquístico / Índice de Masa Corporal / Depresión / Dieta Alta en Grasa / Obesidad Límite: Adult / Animals / Female / Humans Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Síndrome del Ovario Poliquístico / Índice de Masa Corporal / Depresión / Dieta Alta en Grasa / Obesidad Límite: Adult / Animals / Female / Humans Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido