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Altered serum interleukin-17A and interleukin-23A levels may be associated with the pathophysiology and development of generalized anxiety disorder.
Roknuzzaman, A S M; Sarker, Rapty; Nayem, Jannatul; Bhuiyan, Mohiuddin Ahmed; Islam, Md Rabiul; Al Mahmud, Zobaer.
Afiliación
  • Mamun-Or-Rashid; Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
  • Roknuzzaman ASM; Department of Pharmacy, University of Asia Pacific, Dhaka, 1205, Bangladesh.
  • Sarker R; Department of Pharmacy, University of Asia Pacific, Dhaka, 1205, Bangladesh.
  • Nayem J; Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
  • Bhuiyan MA; Department of Pharmacy, University of Asia Pacific, Dhaka, 1205, Bangladesh.
  • Islam MR; School of Pharmacy, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Progati Sarani, Merul Badda, Dhaka, 1212, Bangladesh. robi.ayaan@gmail.com.
  • Al Mahmud Z; Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh. zalmahmud@du.ac.bd.
Sci Rep ; 14(1): 15097, 2024 07 02.
Article en En | MEDLINE | ID: mdl-38956309
ABSTRACT
In recent times, the pathogenesis of generalized anxiety disorder (GAD) and the influence of pro- and anti-inflammatory cytokines on it have garnered considerable interest. Cytokine research, especially Th-17 cytokine research on GAD patients, is limited. Here, we aim to assess the role of interleukin-17A (IL-17A) and interleukin-23A (IL-23A) in the pathophysiology and development of GAD. This investigation included 50 GAD patients and 38 age-sex-matched healthy controls (HCs). A psychiatrist diagnosed patients with GAD and assessed symptom severity using the DSM-5 and the GAD-7 scales. The serum concentrations of IL-17A and IL-23A were determined using commercially available ELISA kits. GAD patients exhibited elevated levels of IL-17A (77.14 ± 58.30 pg/ml) and IL-23A (644.90 ± 296.70 pg/ml) compared to HCs (43.50 ± 25.54 pg/ml and 334.40 ± 176.0 pg/ml). We observed a positive correlation between disease severity and cytokine changes (IL-23A r = 0.359, p = 0.039; IL-17A r = 0.397, p = 0.032). These findings indicate that IL-17A and IL-23A may be associated with the pathophysiology of GAD. ROC analysis revealed moderately higher AUC values (IL-23A 0.824 and IL-17A 0.710), demonstrating their potential to discriminate between patients and HCs. Also, the sensitivity values of both cytokines were relatively higher (IL-23A 80.49% and IL-17A 77.27%). According to the present findings, there may be an association between peripheral serum levels of IL-17A and IL-23A and the pathophysiology and development of GAD. These altered serum IL-17A and IL-23A levels may play a role in directing the early risk of developing GAD. We recommend further research to ascertain their exact role in the pathophysiology and their performance as risk assessment markers of GAD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Interleucina-17 / Subunidad p19 de la Interleucina-23 Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Interleucina-17 / Subunidad p19 de la Interleucina-23 Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Bangladesh Pais de publicación: Reino Unido