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Usefulness of triglyceride-glucose index and homeostatic model assessment for predicting coronary microvascular dysfunction.
Bulut, Mustafa; Celik, Fatma Betul; Guvenc, Tolga Sinan; Yilmaz, Yusuf; Celik, Mehmet; Ozyildirim, Serhan; Gocer, Kemal; Asik, Murat; Kul, Seref; Caliskan, Mustafa.
Afiliación
  • Bulut M; Sultanbeyli State Hospital, Department of Cardiology, Istanbul, Turkey (Dr Bulut).
  • Celik FB; Istanbul Medeniyet University School of Medicine, Department of Cardiology, Istanbul, Turkey (Drs Celik, Yilmaz, Kul and Caliskan).
  • Guvenc TS; Istinye University School of Medicine, Department of Cardiology, Istanbul, Turkey (Dr Guvenc).
  • Yilmaz Y; Istanbul Medeniyet University School of Medicine, Department of Cardiology, Istanbul, Turkey (Drs Celik, Yilmaz, Kul and Caliskan). Electronic address: dr.ysufyilmaz@gmail.com.
  • Celik M; Kartal Kosuyolu Heart and Research Hospital, Department of Cardiology, Istanbul, Turkey (Dr Celik).
  • Ozyildirim S; Istanbul University-Cerrahpasa, Department of Cardiology, Cardiology Institute, Istanbul, Turkey (Dr Ozyildirim).
  • Gocer K; Necip Fazil State Hospital, Department of Cardiology, Kahramanmaras, Turkey.
  • Asik M; Istanbul Medeniyet University School of Medicine (Dr Asik), Department of Radiology, Istanbul, Turkey.
  • Kul S; Istanbul Medeniyet University School of Medicine, Department of Cardiology, Istanbul, Turkey (Drs Celik, Yilmaz, Kul and Caliskan).
  • Caliskan M; Istanbul Medeniyet University School of Medicine, Department of Cardiology, Istanbul, Turkey (Drs Celik, Yilmaz, Kul and Caliskan).
J Clin Lipidol ; 2024 May 06.
Article en En | MEDLINE | ID: mdl-38955587
ABSTRACT

BACKGROUND:

Coronary microvascular dysfunction (CMD) is a common occurrence in individuals with insulin resistance (IR). Homeostatic model assessment for insulin resistance (HOMA-IR) is a widely used surrogate marker of IR, although recent studies suggest Triglyceride-Glucose (TyG) index is a superior marker of IR that had a better accuracy to predict Type 2 Diabetes or cardiovascular outcomes than HOMA-IR.

OBJECTIVES:

We aimed to assess the accuracy and usefulness of TyG index and HOMA-IR for predicting CMD as assessed with echocardiographic coronary flow reserve (CFR) measurement.

METHODS:

All cases included in the institutional CFR registry were retrospectively reviewed, and 656 cases without epicardial coronary artery disease and without major risk factors for atherosclerosis were included. A CFR ≤2.0 was defined as CMD.

RESULTS:

TyG index was available in all cases, while HOMA-IR was available in 398 cases. Both TyG index and HOMA-IR were associated with CMD on univariate analyses, while after adjustment for potential confounders HOMA-IR (OR1.38, 95 %CI1.14-1.67, p = 0.001) but not TyG index(OR1.48, 95 %CI0.82-2.67, p = 0.19) was associated with CMD. The predictive accuracy of HOMA-IR (c-statistic0.63, 95 %CI0.54-0.72, p = 0.003) was higher than TyG index(c-statistic0.55, 95 %CI0.47-0.63, p = 0.13), although the difference was not statistically significant (DeLong p = 0.23). There was strong evidence favoring a true difference between CMD vs. non-CMD groups for HOMA-IR (BF103507) but not for TyG index(BF100.66).

CONCLUSIONS:

HOMA-IR, but not TyG index, is closely associated with CMD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Lipidol Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Lipidol Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos