Association of polymorphisms within P2RX4 with type 2 diabetes mellitus: a preliminary case-control study.
Nucleosides Nucleotides Nucleic Acids
; : 1-11, 2024 Jul 02.
Article
en En
| MEDLINE
| ID: mdl-38954847
ABSTRACT
OBJECTIVE:
Type 2 diabetes mellitus (T2DM) is a complex heterogenic metabolic with a wide range of etiology. Purinergic receptors have pivotal roles in different processes and are hypothesized to have roles in the pathogenesis of T2DM. MATERIALS ANDMETHODS:
Three hundred subjects affected by T2DM and 300 healthy subjects were genotyped by amplification refractory mutation system polymerase chain reaction (ARMS-PCR). SPSS V16.0 was recruited for statistical analysis.RESULTS:
The findings showed that the G allele of rs25644A > G increases the risk of T2DM in our population statistically (OR = 1.51, 95% CI = 1.14-1.99, p = 0.003). This allele in some genotype models, including the dominant model, caused an increase in the risk of T2DM. The interaction of genotypes between studied variants in the P2XR4 gene increased the risk of T2DM. Haplotype analysis showed that Ars1169727/Grs25644 haplotype caused an increase in the risk of T2DM.CONCLUSIONS:
The findings suggest that rs25644A > G plays a role in our population's increased risk of T2DM.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Asunto de la revista:
BIOQUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Estados Unidos