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Relationship between anhedonia and psychosocial functioning in post-COVID-19 condition: a post-hoc analysis.
Liao, Sonya; Teopiz, Kayla M; Kwan, Angela T H; Le, Gia Han; Wong, Sabrina; Ballum, Hana; Rhee, Taeho Greg; Badulescu, Sebastian; Cao, Bing; Guo, Ziji; Meshkat, Shakila; Phan, Lee; Subramaniapillai, Mehala; Ho, Roger; McIntyre, Roger S.
Afiliación
  • Liao S; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
  • Teopiz KM; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
  • Kwan ATH; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
  • Le GH; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
  • Wong S; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
  • Ballum H; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Rhee TG; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
  • Badulescu S; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Cao B; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
  • Guo Z; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Meshkat S; Department of Public Health Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.
  • Phan L; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
  • Subramaniapillai M; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Ho R; Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University, Chongqing, P. R. China.
  • McIntyre RS; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
Curr Med Res Opin ; 40(8): 1407-1411, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38954402
ABSTRACT

BACKGROUND:

Post-COVID-19 condition (PCC), also known as "long COVID," is characterized by persistent symptoms, negatively affecting the well-being of individuals with PCC. Anhedonia (i.e. reduced capacity for pleasure) and compromised psychosocial functioning are notable symptoms in those with PCC. We aimed to provide insights to understand the effects of anhedonia and impaired psychosocial functioning of individuals with PCC.

METHODS:

This post-hoc analysis used data from an 8-week, double-blind, randomized, placebo-controlled trial which evaluated vortioxetine for cognitive deficits in individuals with PCC (Clinicaltrials.gov Identifier NCT05047952). A total of 147 eligible participants were randomly assigned to receive vortioxetine or matching placebo over eight weeks of double-blind treatment. Our study investigated the relationship between anhedonia, assessed by the Snaith-Hamilton Pleasure Scale (SHAPS), and psychosocial functioning, measured with the Post-COVID Functional Status (PCFS) scale. The analysis was conducted using a generalized linear model, with adjustments for relevant covariates such as age, sex, education, suspected versus confirmed COVID diagnosis, MDD diagnosis, and alcohol consumption.

RESULTS:

Of the 147 participants, 143 participants had available baseline data for analysis. We observed that baseline PCFS score was statistically significantly positively correlated to baseline SHAPS score (ß = 0.070, p = 0.045, 95% CI). DISCUSSIONS Our analysis revealed a significant relationship between measures of anhedonia and psychosocial functioning in adults with PCC. Strategies that aim to improve patient-reported outcomes with PCC need to prioritize the prevention and treatment of hedonic disturbances in patients experiencing PCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anhedonia / Funcionamiento Psicosocial / COVID-19 Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Curr Med Res Opin Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anhedonia / Funcionamiento Psicosocial / COVID-19 Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Curr Med Res Opin Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido