Does 'sub-threshold' ventilatory stress promote healing after lung injury?

Marini, John J; Kummer, Rebecca L; Rocco, Patricia R M

Marini, John J; Kummer, Rebecca L; Rocco, Patricia R M.

Afiliación

Marini JJ; Department of Pulmonary and Critical Care Medicine, University of Minnesota, Minneapolis, St Paul, MN, USA. marin002@umn.edu.
Kummer RL; Department of Pulmonary and Critical Care Medicine, University of Minnesota, Minneapolis, St Paul, MN, USA.
Rocco PRM; Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Intensive Care Med Exp ; 12(1): 59, 2024 Jul 02.

Article en En | MEDLINE | ID: mdl-38954123

ABSTRACT

ABSTRACT

Excessive tidal stretching may initiate damage or retard healing after lung injury. However, it is seldom considered whether intracycle power and ventilatory forces of lesser magnitude than those required to cross an injury threshold might stimulate or accelerate beneficial adaptive responses. Acute lung injury is a dynamic process that may exhibit phase-dependent reparative responses to mechanical stress broadly similar to physical training, body trauma or sepsis. We propose that lower stress may not always be better through all phases of ARDS; moderately high tidal airway pressures that stay below the threshold of global injury may have potential to speed healing of the injured lung.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Intensive Care Med Exp Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

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