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Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.
Shao, Min; Qiu, Yujia; Shen, Mengxia; Liu, Wei; Feng, Dandan; Luo, Ziqiang; Zhou, Yan.
Afiliación
  • Shao M; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, China.
  • Qiu Y; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, China.
  • Shen M; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, China.
  • Liu W; Department of Community Nursing, Xiangya Nursing School, Central South University, Changsha, China.
  • Feng D; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, China.
  • Luo Z; Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, China.
  • Zhou Y; Hunan Key Laboratory of Organ Fibrosis, Changsha, China.
FASEB J ; 38(13): e23749, 2024 Jul 15.
Article en En | MEDLINE | ID: mdl-38953707
ABSTRACT
Pulmonary fibrosis is a formidable challenge in chronic and age-related lung diseases. Myofibroblasts secrete large amounts of extracellular matrix and induce pro-repair responses during normal wound healing. Successful tissue repair results in termination of myofibroblast activity via apoptosis; however, some myofibroblasts exhibit a senescent phenotype and escape apoptosis, causing over-repair that is characterized by pathological fibrotic scarring. Therefore, the removal of senescent myofibroblasts using senolytics is an important method for the treatment of pulmonary fibrosis. Procyanidin C1 (PCC1) has recently been discovered as a senolytic compound with very low toxicity and few side effects. This study aimed to determine whether PCC1 could improve lung fibrosis by promoting apoptosis in senescent myofibroblasts and to investigate the mechanisms involved. The results showed that PCC1 attenuates bleomycin (BLM)-induced pulmonary fibrosis in mice. In addition, we found that PCC1 inhibited extracellular matrix deposition and promoted the apoptosis of senescent myofibroblasts by increasing PUMA expression and activating the BAX signaling pathway. Our findings represent a new method of pulmonary fibrosis management and emphasize the potential of PCC1 as a senotherapeutic agent for the treatment of pulmonary fibrosis, providing hope for patients with pulmonary fibrosis worldwide. Our results advance our understanding of age-related diseases and highlight the importance of addressing cellular senescence in treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Bleomicina / Catequina / Senescencia Celular / Miofibroblastos / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Bleomicina / Catequina / Senescencia Celular / Miofibroblastos / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos