Your browser doesn't support javascript.
loading
Corticosterone exposure is associated with long-term changes in DNA methylation, physiology and breeding decisions in a wild bird.
Taff, Conor C; McNew, Sabrina M; Campagna, Leonardo; Vitousek, Maren N.
Afiliación
  • Taff CC; Department of Ecology & Evolutionary Biology and Cornell Lab of Ornithology, Cornell University, Ithaca, New York, USA.
  • McNew SM; Department of Biology, Colby College, Waterville, Maine, USA.
  • Campagna L; Department of Ecology & Evolutionary Biology, University of Arizona, Tucson, Arizona, USA.
  • Vitousek MN; Department of Ecology & Evolutionary Biology and Cornell Lab of Ornithology, Cornell University, Ithaca, New York, USA.
Mol Ecol ; 33(15): e17456, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38953311
ABSTRACT
When facing challenges, vertebrates activate a hormonal stress response that can dramatically alter behaviour and physiology. Although this response can be costly, conceptual models suggest that it can also recalibrate the stress response system, priming more effective responses to future challenges. Little is known about whether this process occurs in wild animals, particularly in adulthood, and if so, how information about prior experience with stressors is encoded. One potential mechanism is hormonally mediated changes in DNA methylation. We simulated the spikes in corticosterone that accompany a stress response using non-invasive dosing in tree swallows (Tachycineta bicolor) and monitored the phenotypic effects 1 year later. In a subset of individuals, we characterized DNA methylation using reduced representation bisulfite sequencing shortly after treatment and a year later. The year after treatment, experimental females had stronger negative feedback and initiated breeding earlier-traits that are associated with stress resilience and reproductive performance in our population-and higher baseline corticosterone. We also found that natural variation in corticosterone predicted patterns of DNA methylation. Finally, corticosterone treatment influenced methylation on short (1-2 weeks) and long (1 year) time scales; however, these changes did not have clear links to functional regulation of the stress response. Taken together, our results are consistent with corticosterone-induced priming of future stress resilience and support DNA methylation as a potential mechanism, but more work is needed to demonstrate functional consequences. Uncovering the mechanisms linking experience with the response to future challenges has implications for understanding the drivers of stress resilience.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corticosterona / Metilación de ADN / Golondrinas Límite: Animals Idioma: En Revista: Mol Ecol Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corticosterona / Metilación de ADN / Golondrinas Límite: Animals Idioma: En Revista: Mol Ecol Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido