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Enterolignans: from natural origins to cardiometabolic significance, including chemistry, dietary sources, bioavailability, and activity.
Laveriano-Santos, Emily P; Luque-Corredera, Carlos; Trius-Soler, Marta; Lozano-Castellón, Julian; Dominguez-López, Inés; Castro-Barquero, Sara; Vallverdú-Queralt, Anna; Lamuela-Raventós, Rosa M; Pérez, Maria.
Afiliación
  • Laveriano-Santos EP; Department of Nutrition, Food Science and Gastronomy, XIA, Faculty of Pharmacy and Food Sciences, Polyphenol Research Group, University of Barcelona, Barcelona, Spain.
  • Luque-Corredera C; INSA-UB, Nutrition and Food Safety Research Institute, University of Barcelona, Santa Coloma de Gramanet, Spain.
  • Trius-Soler M; CIBER Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
  • Lozano-Castellón J; Salesian University School of Sarrià (EUSS), Barcelona, Spain.
  • Dominguez-López I; Department of Nutrition, Food Science and Gastronomy, XIA, Faculty of Pharmacy and Food Sciences, Polyphenol Research Group, University of Barcelona, Barcelona, Spain.
  • Castro-Barquero S; INSA-UB, Nutrition and Food Safety Research Institute, University of Barcelona, Santa Coloma de Gramanet, Spain.
  • Vallverdú-Queralt A; CIBER Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
  • Lamuela-Raventós RM; Department of Nutrition, Food Science and Gastronomy, XIA, Faculty of Pharmacy and Food Sciences, Polyphenol Research Group, University of Barcelona, Barcelona, Spain.
  • Pérez M; INSA-UB, Nutrition and Food Safety Research Institute, University of Barcelona, Santa Coloma de Gramanet, Spain.
Crit Rev Food Sci Nutr ; : 1-21, 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38952149
ABSTRACT
The enterolignans, enterolactone and enterodiol, the main metabolites produced from plant lignans by the gut microbiota, have enhanced bioavailability and activity compared to their precursors, with beneficial effects on metabolic and cardiovascular health. Although extensively studied, the biosynthesis, cardiometabolic effects, and other therapeutic implications of mammalian lignans are still incompletely understood. The aim of this review is to provide a comprehensive overview of these phytoestrogen metabolites based on up-to-date information reported in studies from a wide range of disciplines. Established and novel synthetic strategies are described, as are the various lignan precursors, their dietary sources, and a proposed metabolic pathway for their conversion to enterolignans. The methodologies used for enterolignan analysis and the available data on pharmacokinetics and bioavailability are summarized and their cardiometabolic bioactivity is explored in detail. The special focus given to research on the health benefits of microbial-derived lignan metabolites underscores the critical role of lignan-rich diets in promoting cardiovascular health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Crit Rev Food Sci Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Crit Rev Food Sci Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos