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Characterization of stromal calcifications in odontogenic keratocyst: a multicentric study.
Desai, Karishma Madhusudan; Tanaka, Yoichi; Angadi, Punnya V; Kheur, Supriya Mohit; Puranik, Uday; Tatsumi, Ayaka; Sekikawa, Shoichi; Nomura, Takeshi.
Afiliación
  • Desai KM; Oral Health Science Centre, Tokyo Dental College, 2 Chome-9-18 Misakicho, Chiyoda City, Tokyo, 101-0061, Japan. desaikarishma@tdc.ac.jp.
  • Tanaka Y; Division of Surgical Pathology, Clinical Laboratory, Ichikawa General Hospital, Tokyo Dental College, Sugano Ichikawa-shi, Chiba, 272-8513, Japan.
  • Angadi PV; Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research (KLE University), Belagavi, 590010, India.
  • Kheur SM; Dr.D.Y.Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, India.
  • Puranik U; Consultant Oral and Maxillofacial Pathologist, Thane, India.
  • Tatsumi A; Department of Oral and Maxillofacial surgery, Tokyo Dental College, Sugano Ichikawa-shi, Chiba, 272-8513, Japan.
  • Sekikawa S; Department of Oral and Maxillofacial surgery, Tokyo Dental College, Sugano Ichikawa-shi, Chiba, 272-8513, Japan.
  • Nomura T; Department of Oral and Maxillofacial surgery, Tokyo Dental College, Sugano Ichikawa-shi, Chiba, 272-8513, Japan.
Odontology ; 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38951299
ABSTRACT
Odontogenic keratocysts (OKCs) are locally aggressive cysts that exhibit typical histopathological features and have a propensity for recurrence. Though histological variations are observed in OKCs, hard tissue formation and metaplastic changes are rare, and the underlying pathogenesis is not well understood. This study aimed to characterize stromal calcifications and analyze their association with odontogenic components in non-syndromic and syndrome-associated cases of OKCs. We analyzed 153 cases of OKCs from healthcare institutes in India and Japan. The epithelial and stromal features were evaluated, and the relationship of calcifications with odontogenic rests was determined. Immunohistochemistry for cytokeratin-19 and special stains including Masson Trichrome and Van Gieson, were used for identification of odontogenic rests and calcifications respectively. Stromal calcifications were observed in 29.41% OKCs. The calcification patterns included irregular dystrophic, dentinoid with linear or calcospherite-type mineralization, and psammoma calcifications. Psammoma and dentinoid calcifications were found in the proximity of cytokeratin-19-positive odontogenic rests or satellite cysts, whereas majority cases with dystrophic calcifications did not exhibit co-localization with stromal odontogenic components. Distinct patterns of calcifications were observed in OKCs. Calcifications found in proximity of the odontogenic rests were possibly indicative of an inductive or host-mediated response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Odontology Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Odontology Asunto de la revista: ODONTOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón