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Factors linked to prognosis in children with provisional tic disorder: a prospective cohort study.
Liu, Fang; Fan, Chuangang; Yao, Baozhen; Liu, Hong; Wang, Huaqian; Ye, Jingping; Wang, Gaohua.
Afiliación
  • Liu F; Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
  • Fan C; Institute of Health Surveillance, Analysis and Protection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, 430079, China.
  • Yao B; Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
  • Liu H; Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
  • Wang H; Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China.
  • Ye J; Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China. jpy7012@163.com.
  • Wang G; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China. wgh6402@whu.edu.cn.
Eur J Pediatr ; 183(9): 4009-4017, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38951254
ABSTRACT
The purpose of the present study was to estimate the factors linked to the prognosis of children with provisional tic disorder (PTD). We conducted a prospective cohort study enrolled children with PTD who were subsequently followed-up at three-month intervals for 1 year post-enrolment. A total of 259 PTD patients were included in the final analysis. At the end of the follow-up period, 77 (30%) of the patients had achieved clinical remission. Result of the LASSO logistic regression analysis revealed that a disease duration >3 months (OR=4.20, 95% CI 1.20-14.73), moderate/severe tic severity (OR=5.57, 95% CI 2.26-13.76), and comorbid behavioral problems (OR=2.78, 95% CI 1.15-6.69) were significant factors linked to remission in the PTD patients. The path analysis model showed that comorbid behavioral problems and recurrence partially mediated the association between tic severity and remission, with a mediating effect of 37%.

Conclusions:

We have identified several significant factors linked to prognosis in children with PTD, including comorbid behavioral problems and recurrence, which were found to be important mediators. These findings provide new insights for the clinical management of patients with PTD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Tic Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Eur J Pediatr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Tic Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Eur J Pediatr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania