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Cannabis use and acute postoperative pain outcomes in older adults: a propensity matched retrospective cohort study.
Sajdeya, Ruba; Rouhizadeh, Masoud; Cook, Robert L; Ison, Ronald L; Bai, Chen; Jugl, Sebastian; Gao, Hanzhi; Mardini, Mamoun T; Dasa, Osama; Zandbiglari, Kimia; Adiba, Farzana I; Winterstein, Almut G; Price, Catherine C; Pearson, Thomas A; Seubert, Christoph N; Tighe, Patrick J.
Afiliación
  • Sajdeya R; University of Florida, Gainesville, Florida, USA rubasajdeya@ufl.edu.
  • Rouhizadeh M; University of Florida, Gainesville, Florida, USA.
  • Cook RL; University of Florida, Gainesville, Florida, USA.
  • Ison RL; University of Florida, Gainesville, Florida, USA.
  • Bai C; University of Florida, Gainesville, Florida, USA.
  • Jugl S; University of Florida, Gainesville, Florida, USA.
  • Gao H; University of Florida, Gainesville, Florida, USA.
  • Mardini MT; University of Florida, Gainesville, Florida, USA.
  • Dasa O; University of Florida, Gainesville, Florida, USA.
  • Zandbiglari K; University of Florida, Gainesville, Florida, USA.
  • Adiba FI; University of Florida, Gainesville, Florida, USA.
  • Winterstein AG; University of Florida, Gainesville, Florida, USA.
  • Price CC; University of Florida, Gainesville, Florida, USA.
  • Pearson TA; University of Florida, Gainesville, Florida, USA.
  • Seubert CN; University of Florida, Gainesville, Florida, USA.
  • Tighe PJ; University of Florida, Gainesville, Florida, USA.
Reg Anesth Pain Med ; 2024 Jun 30.
Article en En | MEDLINE | ID: mdl-38950932
ABSTRACT

INTRODUCTION:

Cannabis use is increasing among older adults, but its impact on postoperative pain outcomes remains unclear in this population. We examined the association between cannabis use and postoperative pain levels and opioid doses within 24 hours of surgery.

METHODS:

We conducted a propensity score-matched retrospective cohort study using electronic health records data of 22 476 older surgical patients with at least 24-hour hospital stays at University of Florida Health between 2018 and 2020. Of the original cohort, 2577 patients were eligible for propensity-score matching (13 cannabis user non-user). Cannabis use status was determined via natural language processing of clinical notes within 60 days of surgery and structured data. The primary outcomes were average Defense and Veterans Pain Rating Scale (DVPRS) score and total oral morphine equivalents (OME) within 24 hours of surgery.

RESULTS:

504 patients were included (126 cannabis users and 378 non-users). The median (IQR) age was 69 (65-72) years; 295 (58.53%) were male, and 442 (87.70%) were non-Hispanic white. Baseline characteristics were well balanced. Cannabis users had significantly higher average DVPRS scores (median (IQR) 4.68 (2.71-5.96) vs 3.88 (2.33, 5.17); difference=0.80; 95% confidence limit (CL), 0.19 to 1.36; p=0.01) and total OME (median (IQR) 42.50 (15.00-60.00) mg vs 30.00 (7.50-60.00) mg; difference=12.5 mg; 95% CL, 3.80 mg to 21.20 mg; p=0.02) than non-users within 24 hours of surgery.

DISCUSSION:

This study showed that cannabis use in older adults was associated with increased postoperative pain levels and opioid doses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Reg Anesth Pain Med Asunto de la revista: ANESTESIOLOGIA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Reg Anesth Pain Med Asunto de la revista: ANESTESIOLOGIA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido