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Population-based Study of Gastric Cancer Survival and Associations in Rural Western Honduras.
Dominguez, Ricardo L; Montalvan-Sanchez, Eleazar E; Norwood, Dalton A; Rodriguez-Murillo, Aida; Dominguez, Lucia; Estevez Ordoñez, Dagoberto; Beasley, Timothy; Bravo, Luis Eduardo; Morgan, Douglas R.
Afiliación
  • Dominguez RL; Hospital de Occidente, Ministry of Health, Santa Rosa de Copan, Copan, Honduras.
  • Montalvan-Sanchez EE; Indiana University Hospital, Indianapolis, Indiana, United States.
  • Norwood DA; University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Rodriguez-Murillo A; Hospital de Occidente, Ministry of Health, Santa Rosa de Copan, Copan, Honduras.
  • Dominguez L; Hospital de Occidente, Ministry of Health, Santa Rosa de Copan, Copan, Honduras.
  • Estevez Ordoñez D; University of Alabama at Birmingham, Birmingham, AL, United States.
  • Beasley T; University of Alabama at Birmingham, Birmingham, AL, United States.
  • Bravo LE; Universidad del Valle, Cali, Colombia.
  • Morgan DR; University of Alabama School of Medicine, Birmingham, Alabama, United States.
Cancer Epidemiol Biomarkers Prev ; 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38949525
ABSTRACT

BACKGROUND:

Two-thirds of global cancer occur in low/middle income countries (LMICs). Northern Central America is the largest LMIC region in the western hemisphere, and lack cancer registries to guide cancer control. We conducted a gastric cancer (GC) survival study in rural western Honduras, characterized as having among the highest GC incidence rates in Latin America.

METHODS:

The cohort of incident GC diagnosed between 2002-2015 was studied with active follow-up, with household visits. The regional gastric cancer registry was primary for case identification, with completeness examination with hospital data and national death certificates. Cox regression models were used for survival calculations.

RESULTS:

Survival follow-up was achieved in 741/774 patients (95.7%). Household interviews were conducted in 74.1% (n=549). 65.7% were male, median age at diagnosis was 64 years, 24.5% were <55. 43.9% of tumors had pyloric obstruction. 45.2%, 43.2%, and 7.3% of histology was intestinal, diffuse, and mixed, respectively. 24.7% patients received treatment. 5-year survival rates were 9.9% for both males and females, 7.7% for age <45, and 7.9% for diffuse GC. Median survival time was 4.8 months (95%CI,4.2-5.6). In the final Cox regression model including age, sex, Lauren subtype, and poverty index, only treatment was significantly associated with survival (HR 2.43, 95%CI,1.8-3.2).

CONCLUSIONS:

Markedly low gastric cancer 5-year survival rates are observed in rural Central America. The majority of patients present with advanced disease, and a minority have access to therapy. IMPACT The findings have implications for cancer control in the Central America LMICs and for U.S. Latino populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE País/Región como asunto: America central / Honduras Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Asunto de la revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Honduras Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE País/Región como asunto: America central / Honduras Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Asunto de la revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Honduras Pais de publicación: Estados Unidos