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Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients.
Li, Qian; Yu, Yue; Zhou, Ya-Qiong; Zhao, Yi; Wu, Jin; Wu, Yuan-Jing; DU, Bin; Wang, Pei-Jian; Zheng, Tao.
Afiliación
  • Li Q; Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Yu Y; Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Zhou YQ; Department of Cardiology, First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
  • Zhao Y; Department of Neurology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Wu J; Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Wu YJ; Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • DU B; Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Wang PJ; Department of Cardiology, First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
  • Zheng T; Department of Cardiovascular Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
J Geriatr Cardiol ; 21(5): 542-549, 2024 May 28.
Article en En | MEDLINE | ID: mdl-38948892
ABSTRACT

BACKGROUND:

The neutrophil to lymphocyte ratio (NLR) has been reported as a novel predictor for atherosclerosis and cardiovascular outcomes. This study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion (CTO) patients.

METHODS:

A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up period. Patients were divided into tertiles according to their baseline NLR levels at admission low (n = 223), intermediate (n = 223), and high (n = 224). The incidence of major adverse cardiac events (MACEs) during the follow-up period, including all-cause death, nonfatal myocardial infarction (MI), or ischemia-driven revascularization, were compared among the three groups.

RESULTS:

Major adverse cardiac events were observed in 27 patients (12.1%) in the low tertile, 40 (17.9%) in the intermediate tertile, and 61 (27.2%) in the high NLR tertile (P < 0.001). Kaplan-Meier analysis demonstrated a significantly higher incidence of MACE, ischemia-driven coronary revascularization, non-fatal MI, and mortality in patients within the high tertile than those in the low and intermediate groups (all P < 0.001). Multivariable COX regression analysis showed that the high tertile of baseline NLR level showed a strong association with the risk of MACE (hazard ratio [HR] = 2.21; 95% confidence interval [CI] 1.21-4.03; P = 0.009), ischemia-driven coronary revascularization (HR = 3.19; 95% CI 1.56-6.52; P = 0.001), MI (HR = 2.61; 95% CI 1.35-5.03; P = 0.043) and mortality (HR = 3.78; 95% CI 1.65-8.77; P = 0.001).

CONCLUSION:

Our findings suggest that NLR is an inexpensive and readily available biomarker that can independently predict cardiovascular risk in patients with CTO.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Geriatr Cardiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Geriatr Cardiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China