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Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase.
Huang, De-Liang; Cai, Qin-Xian; Zhou, Guang-De; Yu, Hong; Zhu, Zhi-Bin; Peng, Jing-Han; Chen, Jun.
Afiliación
  • Huang DL; Department of Liver Diseases, The Third People's Hospital of Shenzhen, Shenzhen 510000, Guangdong Province, China.
  • Cai QX; Department of Liver Diseases, The Third People's Hospital of Shenzhen, Shenzhen 510000, Guangdong Province, China.
  • Zhou GD; Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing 100000, China.
  • Yu H; Department of Pathology, National Clinical Research Centre for Infectious Disease, The Third People's Hospital of Shenzhen and the Second Hospital Affiliated with the Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China.
  • Zhu ZB; Department of Liver Diseases, The Third People's Hospital of Shenzhen, Shenzhen 510000, Guangdong Province, China.
  • Peng JH; Department of Liver Diseases, The Third People's Hospital of Shenzhen, Shenzhen 510000, Guangdong Province, China.
  • Chen J; Department of Liver Diseases, The Third People's Hospital of Shenzhen, Shenzhen 510000, Guangdong Province, China. drchenjun@163.com.
World J Hepatol ; 16(6): 920-931, 2024 Jun 27.
Article en En | MEDLINE | ID: mdl-38948441
ABSTRACT

BACKGROUND:

Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B (CHB) patients were not previously conducted.

AIM:

To assess the liver histological changes in the indeterminate phase CHB patients using liver biopsy.

METHODS:

The clinical and laboratory data of 1532 untreated CHB patients were collected, and all patients had least once liver biopsy from January 2015 to December 2021. The significant differences among different phases of CHB infection were compared with t-test, and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression analysis.

RESULTS:

Among 1532 untreated CHB patients, 814 (53.13%) patients were in the indeterminate phase. Significant liver histological changes (defined as biopsy score ≥ G2 and/or ≥ S2) were found in 488/814 (59.95%) CHB patients in the indeterminate phase. Significant liver histological changes were significant differences among different age, platelets (PLTs), and alanine aminotransferase (ALT) subgroup in indeterminate patient. Multivariate logistic regression analysis indicated that age ≥ 40 years old [adjust odd risk (aOR), 1.44; 95% confidence interval (CI) 1.06-1.97; P = 0.02], PLTs ≤ 150 × 109/L (aOR, 2.99; 95%CI 1.85-4.83; P < 0.0001), and ALT ≥ upper limits of normal (aOR, 1.48; 95%CI 1.08, 2.05, P = 0.0163) were independent risk factors for significant liver histological changes in CHB patients in the indeterminate phase.

CONCLUSION:

Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase, and additional strategies are urgently required for the management of these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Hepatol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: World J Hepatol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos