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Naringin mitigates testicular injury and associated neuronal toxicity in lead-exposed cockerel chicks.
Esan, Oluwaseun Olanrewaju; Ebirim, Chinomso Gift; Adetona, Moses Olusola; Ajibade, Temitayo Olabisi; Oyagbemi, Ademola Adetokunbo; Omobowale, Temidayo Olutayo; Oladele, Omolade Abodunrin; Adedapo, Adeolu Alex; Yakubu, Momoh Audu; Nwulia, Evaristus; Oguntibeju, Oluwafemi Omoniyi.
Afiliación
  • Esan OO; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
  • Ebirim CG; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
  • Adetona MO; Department of Anatomy, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria.
  • Ajibade TO; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
  • Oyagbemi AA; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
  • Omobowale TO; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
  • Oladele OA; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
  • Adedapo AA; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Nigeria.
  • Yakubu MA; Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, COPHS, Texas Southern University, Houston, TX, USA.
  • Nwulia E; Howard University, College of Medicine, Department of Psychiatry and Behavioral Sciences, Howard University Hospital, 2041 Georgia Avenue, Washington, DC 20060, USA.
  • Oguntibeju OO; Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa.
Avicenna J Phytomed ; 14(1): 50-63, 2024.
Article en En | MEDLINE | ID: mdl-38948173
ABSTRACT

Objective:

Lead (Pb) poisoning affects multiple organs including the reproductive system. The experiment was performed to explore the protective effect of naringin on testicular apoptosis, neuronal dysfunction and markers of stress in cockerel chicks. Materials and

Methods:

Thirty-six cockerel chicks were used for this study, and randomly grouped into six chicks per group viz. control, Pb only (600 ppm), Pb and naringin (80 mg/kg), Pb and Naringin (160 mg/kg), naringin only (80 mg/kg) and naringin only (160 mg/kg), respectively, for eight weeks. Pb was administered via drinking water while naringin was administered via oral gavage. Oxidative stress indices in the brain and testes were assessed, and immunohistochemistry of TNF-α and caspase 3 was done in the brain and testes, respectively.

Results:

Lead administration induced inflammatory and testicular apoptosis cascade accompanied with increased oxidative stress and upregulation of brain and testicular antioxidant enzymes in comparison to the control and Pb-only-treated cockerels. Immunohistochemistry showed significant immunoreactivity of testicular caspase 3 and TNF-α in the brain.

Conclusion:

Treatment of Pb-exposed chickens with naringin offered protection to Pb acetate-induced testicular oxidative stress, apoptosis, and neuroinflammation in cockerel chicks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Avicenna J Phytomed Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Irán
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Avicenna J Phytomed Año: 2024 Tipo del documento: Article País de afiliación: Nigeria Pais de publicación: Irán