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Imaging of colorectal adenomas with pseudoinvasion and malignant polyps using two-photon excitation microscopy.
Florea, Maria-Alexandra; Eftimie, Lucian George; Glogojeanu, Remus Relu; Hristu, Radu; Stanciu, George A; Costache, Mariana.
Afiliación
  • Florea MA; Pathology Department, Central University Emergency Military Hospital, Bucharest, Romania.
  • Eftimie LG; Pathology Department, University of Medicine and Pharmacy, Carol Davila', Bucharest, Romania.
  • Glogojeanu RR; Pathology Department, Central University Emergency Military Hospital, Bucharest, Romania.
  • Hristu R; Center for Microscopy-Microanalysis and Information Processing, National University of Science and Technology Politehnica Bucharest, Bucharest, Romania.
  • Stanciu GA; Department of Special Motricity and Medical Recovery, The National University of Physical Education and Sports, Bucharest, Romania.
  • Costache M; Department of Special Motricity and Medical Recovery, The National University of Physical Education and Sports, Bucharest, Romania.
Front Oncol ; 14: 1394493, 2024.
Article en En | MEDLINE | ID: mdl-38947893
ABSTRACT

Introduction:

Although the incidence and mortality rates of colorectal cancer exhibit significant variability, it remains one of the most prevalent cancers worldwide. Endeavors to prevent colorectal cancer development focus on detecting precursor lesions during colonoscopy. The diagnosis of endoscopically resected polyps relies on hematoxylin and eosin staining examination. For challenging cases like adenomatous polyps with epithelial misplacement, additional diagnostic methods could prove beneficial.

Methods:

This paper aims to underscore stromal changes observed in malignant polyps and polyps with pseudoinvasion, leveraging two-photon excitation microscopy (TPEM), a technique extensively employed in the medical field in recent years. Results and discussions Both the subjective and quantitative analysis of TPEM images revealed distinct distributions and densities of collagen at the invasion front in malignant polyps compared to areas of pseudoinvasion. TPEM holds potential in discerning true invasion in malignant polyps from pseudoinvasion, offering enhanced visualization of local stromal changes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2024 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza