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Causal relationship between Helicobacter pylori infection and IgA nephropathy: a bidirectional two-sample mendelian randomization study.
Jing, Shuhui; Lin, Ling; Li, Jiaxing; Pan, Juan; Qiao, Xi.
Afiliación
  • Jing S; Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
  • Lin L; Shanxi Kidney Disease Institute, Taiyuan, People's Republic of China.
  • Li J; Kidney Research Center of Shanxi Medical University, Taiyuan, People's Republic of China.
  • Pan J; Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
  • Qiao X; Shanxi Kidney Disease Institute, Taiyuan, People's Republic of China.
Ren Fail ; 46(2): 2371055, 2024 Dec.
Article en En | MEDLINE | ID: mdl-38946159
ABSTRACT
IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis, and serum Helicobacter pylori (H. pylori) antibody levels are increased in patients with IgA N, but the role of H. pylori infection in the pathogenesis of IgAN is unclear. In this study, we investigated whether there is a causal relationship and reverse causality between IgAN and H. pylori infection by using a bidirectional two-sample Mendelian randomization (MR) analysis. This study was estimated using inverse variance weighted (IVW), MR-Egger and weighted median methods, with the IVW method having the strongest statistical efficacy. Seven common serum H. pylori antibodies were selected as exposure factors for positive MR analysis. The results showed that there was no evidence of a causal relationship between H. pylori infection and IgAN. Reverse MR analysis showed that there was also no evidence that the occurrence of IgAN leads to an increased risk of H. pylori infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Análisis de la Aleatorización Mendeliana / Glomerulonefritis por IGA Límite: Humans Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Análisis de la Aleatorización Mendeliana / Glomerulonefritis por IGA Límite: Humans Idioma: En Revista: Ren Fail Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido