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Data-driven mathematical modeling of sleep consolidation in early childhood.
Athanasouli, Christina; Stowe, Shelby R; LeBourgeois, Monique K; Booth, Victoria; Diniz Behn, Cecilia G.
Afiliación
  • Athanasouli C; Department of Mathematics, University of Michigan, 530 Church Street, Ann Arbor, MI, 48109, USA; School of Mathematics, Georgia Institute of Technology, 686 Cherry St NW, Atlanta, GA, 30332, USA. Electronic address: cathanasouli3@gatech.edu.
  • Stowe SR; Department of Applied Mathematics and Statistics, Colorado School of Mines, 1500 Illinois Street, Golden, CO, 80401, USA. Electronic address: sstowe@mines.edu.
  • LeBourgeois MK; Department of Integrative Physiology, University of Colorado, 354 UCB, Boulder, CO, 80309, USA. Electronic address: Monique.LeBourgeois@colorado.edu.
  • Booth V; Department of Mathematics, University of Michigan, 530 Church Street, Ann Arbor, MI, 48109, USA; Department of Anesthesiology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, 48109-5048, USA. Electronic address: vbooth@umich.edu.
  • Diniz Behn CG; Department of Applied Mathematics and Statistics, Colorado School of Mines, 1500 Illinois Street, Golden, CO, 80401, USA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, 13001 East 17th Place, Aurora, CO, 80045, USA. Electronic address: cdinizbe@mines.edu.
J Theor Biol ; 593: 111892, 2024 10 07.
Article en En | MEDLINE | ID: mdl-38945471
ABSTRACT
Across early childhood development, sleep behavior transitions from a biphasic pattern (a daytime nap and nighttime sleep) to a monophasic pattern (only nighttime sleep). The transition to consolidated nighttime sleep, which occurs in most children between 2- and 5-years-old, is a major developmental milestone and reflects interactions between the developing homeostatic sleep drive and circadian system. Using a physiologically-based mathematical model of the sleep-wake regulatory network constrained by observational and experimental data from preschool-aged participants, we analyze how developmentally-mediated changes in the homeostatic sleep drive may contribute to the transition from napping to non-napping sleep patterns. We establish baseline behavior by identifying parameter sets that model typical 2-year-old napping behavior and 5-year-old non-napping behavior. Then we vary six model parameters associated with the dynamics of and sensitivity to the homeostatic sleep drive between the 2-year-old and 5-year-old parameter values to induce the transition from biphasic to monophasic sleep. We analyze the individual contributions of these parameters to sleep patterning by independently varying their age-dependent developmental trajectories. Parameters vary according to distinct evolution curves and produce bifurcation sequences representing various ages of transition onset, transition durations, and transitional sleep patterns. Finally, we consider the ability of napping and non-napping light schedules to reinforce napping or promote a transition to consolidated sleep, respectively. These modeling results provide insight into the role of the homeostatic sleep drive in promoting interindividual variability in developmentally-mediated transitions in sleep behavior and lay foundations for the identification of light- or behavior-based interventions that promote healthy sleep consolidation in early childhood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño Límite: Child, preschool / Female / Humans / Male Idioma: En Revista: J Theor Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño Límite: Child, preschool / Female / Humans / Male Idioma: En Revista: J Theor Biol Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido