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Co-existence of Neurotrophic Keratopathy in Eyes With Limbal Stem Cell Deficiency.
Niruthisard, Duangratn; Bonnet, Clémence; Fung, Simon S M; Unhale, Rutuja; Tseng, Chi-Hong; Muntham, Dittapol; Deng, Sophie X.
Afiliación
  • Niruthisard D; From the Stein Eye Institute (D.N., C.B., S.S.M.F., R.U., S.X.D.), David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Ophthalmology (D.N.), Banphaeo General Hospital, Samut Sakhon, Thailand.
  • Bonnet C; From the Stein Eye Institute (D.N., C.B., S.S.M.F., R.U., S.X.D.), David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Centre de Recherche des Cordeliers (C.B.), INSERM 1138, Paris Cité Université, AP-HP, F-75014, Paris, France.
  • Fung SSM; From the Stein Eye Institute (D.N., C.B., S.S.M.F., R.U., S.X.D.), David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Unhale R; From the Stein Eye Institute (D.N., C.B., S.S.M.F., R.U., S.X.D.), David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Tseng CH; Division of General Internal Medicine and Health Services Research (C.-H.T.), David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
  • Muntham D; Section for Mathematics (D.M.), Faculty of Science and Technology, Rajamangala University of Technology Suvarnabhumi, Thailand.
  • Deng SX; From the Stein Eye Institute (D.N., C.B., S.S.M.F., R.U., S.X.D.), David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Molecular Biology Institute (S.X.D.), University of California, Los Angeles, California, USA. Electronic address: deng@jsei.ucla.edu.
Am J Ophthalmol ; 267: 249-256, 2024 Jun 29.
Article en En | MEDLINE | ID: mdl-38945348
ABSTRACT

PURPOSE:

To investigate whether neurotrophic keratopathy is present in limbal stem cell deficiency (LSCD), by measuring corneal sensation and characterizing corneal subbasal nerve plexus.

DESIGN:

Prospective, cross-sectional, case-control comparative study.

METHODS:

A total of 46 eyes with LSCD and 14 normal eyes were recruited from 2019 to 2022. Corneal sensation was measured using a Cochet-Bonnet esthesiometer, and subbasal nerve plexus was imaged using in vivo confocal microscopy (IVCM) at the central cornea and 4 limbal regions. Subbasal nerve density (SND, number of nerves/mm2), subbasal nerve length (SNL, total length of nerves/mm2) and subbasal nerve branch density (SNBD, number of branches/mm2) were quantified. LSCD was graded to stage 1, 2, and 3 using a previously established staging method consisting of clinical scores, basal cell density, central corneal epithelial thickness, and SNL.

RESULTS:

The mean (±SD) cornea sensation in the central cornea and limbus were 29.2 ± 21.5 and 33.6 ± 15.1 mm in the LSCD group and 57.6 ± 5.8 and 54.3 ± 4.7 mm in the control group, respectively (all P < .001). In sectoral LSCD, the corneal sensation in the affected regions (29.1 ± 17.6 mm) decreased significantly compared to the unaffected regions (41.4 ± 18.2 mm, P < .001). Central corneal SND, SNL, and SNBD were reduced by 84.6%, 82.6%, and 89.2%, respectively, in LSCD compared to controls (all P < 0.05). The central corneal sensation negatively correlated with the severity of LSCD (rho = -0.64, P < .0001) and positively correlated with SND, SNL, and SNBD (rho = 0.63, 0.66, and 0.56, respectively; all P < .001).

CONCLUSIONS:

Corneal sensation was reduced in eyes with LSCD. The degree of corneal sensation reduction positively correlated with the severity of LSCD. This finding demonstrated the coexistence of neurotropic keratopathy in LSCD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Ophthalmol Año: 2024 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Estados Unidos