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Green synthesis of chitosan gum acacia based biodegradable polymeric nanoparticles to enhance curcumin's antioxidant property: an in vivo zebrafish (Danio rerio) study.
Singha, Achinta; Kalladka, Krithika; Harshitha, Mave; Saha, Partha; Chakraborty, Gunimala; Maiti, Biswajit; Satyaprasad, Akshath Uchangi; Chakraborty, Anirban; Sil, Samir Kumar.
Afiliación
  • Singha A; Cancer Biology, Cell Signalling and Molecular Genetics Lab, Department of Human Physiology, Tripura University, Suryamaninagar, India.
  • Kalladka K; Department of Molecular Genetics and Cancer, NITTE University Centre for Science Education and research, NITTE (Deemed to be University), Mangalore, India.
  • Harshitha M; Department of Bio & Nano Technology, NITTE University Centre for Science Education and research, NITTE (Deemed to be University), Mangalore, India.
  • Saha P; Cancer Biology, Cell Signalling and Molecular Genetics Lab, Department of Human Physiology, Tripura University, Suryamaninagar, India.
  • Chakraborty G; Department of Molecular Genetics and Cancer, NITTE University Centre for Science Education and research, NITTE (Deemed to be University), Mangalore, India.
  • Maiti B; Department of Bio & Nano Technology, NITTE University Centre for Science Education and research, NITTE (Deemed to be University), Mangalore, India.
  • Satyaprasad AU; Department of Bio & Nano Technology, NITTE University Centre for Science Education and research, NITTE (Deemed to be University), Mangalore, India.
  • Chakraborty A; Department of Molecular Genetics and Cancer, NITTE University Centre for Science Education and research, NITTE (Deemed to be University), Mangalore, India.
  • Sil SK; Cancer Biology, Cell Signalling and Molecular Genetics Lab, Department of Human Physiology, Tripura University, Suryamaninagar, India.
J Microencapsul ; 41(5): 390-401, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38945157
ABSTRACT
Green-synthesis of biodegradable polymeric curcumin-nanoparticles using affordable biodegradable polymers to enhance curcumin's solubility and anti-oxidative potential. The curcumin-nanoparticle was prepared based on the ionic-interaction method without using any chemical surfactants, and the particle-size, zeta-potential, surface-morphology, entrapmentefficiency, and in-vitro drug release study were used to optimise the formulation. The antioxidant activity was investigated using H2DCFDA staining in the zebrafish (Danio rerio) model. The mean-diameter of blank nanoparticles was 178.2 nm (±4.69), and that of curcuminnanoparticles was about 227.7 nm (±10.4), with a PDI value of 0.312 (±0.023) and 0.360 (±0.02). The encapsulation-efficacy was found to be 34% (±1.8), with significantly reduced oxidative-stress and toxicity (∼5 times) in the zebrafish model compared to standard curcumin. The results suggested that the current way of encapsulating curcumin using affordable, biodegradable, natural polymers could be a better approach to enhancing curcumin's water solubility and bioactivity, which could further be translated into potential therapeutics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Curcumina / Quitosano / Nanopartículas / Tecnología Química Verde / Goma Arábiga / Antioxidantes Límite: Animals Idioma: En Revista: J Microencapsul Asunto de la revista: FARMACIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Curcumina / Quitosano / Nanopartículas / Tecnología Química Verde / Goma Arábiga / Antioxidantes Límite: Animals Idioma: En Revista: J Microencapsul Asunto de la revista: FARMACIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido