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Basophil differentiation, heterogeneity, and functional implications.
Chen, Yan; Tang, Haoyu; Yao, Bingpeng; Pan, Sheng; Ying, Songmin; Zhang, Chao.
Afiliación
  • Chen Y; Department of Pharmacy, Center for Regeneration and Aging Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Yiwu, 322000, China.
  • Tang H; Department of Pharmacy, Center for Regeneration and Aging Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Yiwu, 322000, China.
  • Yao B; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, 310058, China
  • Pan S; Department of Pharmacy, Center for Regeneration and Aging Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Yiwu, 322000, China; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, 310
  • Ying S; Department of Pharmacy, Center for Regeneration and Aging Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Yiwu, 322000, China; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respira
  • Zhang C; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China; Department of Anatomy, Zhejiang University School of Medicine, Hangzhou, 310058, China. Ele
Trends Immunol ; 45(7): 523-534, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38944621
ABSTRACT
Basophils, rare granulocytes, have long been acknowledged for their roles in type 2 immune responses. However, the mechanisms by which basophils adapt their functions to diverse mammalian microenvironments remain unclear. Recent advancements in specific research tools and single-cell-based technologies have greatly enhanced our understanding of basophils. Several studies have shown that basophils play a role in maintaining homeostasis but can also contribute to pathology in various tissues and organs, including skin, lung, and others. Here, we provide an overview of recent basophil research, including cell development, characteristics, and functions. Based on an increasing understanding of basophil biology, we suggest that the precise targeting of basophil features might be beneficial in alleviating certain pathologies such as asthma, atopic dermatitis (AD), and others.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Basófilos / Diferenciación Celular Límite: Animals / Humans Idioma: En Revista: Trends Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Basófilos / Diferenciación Celular Límite: Animals / Humans Idioma: En Revista: Trends Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido