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Cross-sectional association between posttraumatic stress and cognition is moderated by pulmonary functioning in world trade center responders.
Choi, Jaeun; Hall, Charles B; Clouston, Sean A P; Cleven, Krystal L; Mann, Frank D; Luft, Benjamin J; Zammit, Andrea R.
Afiliación
  • Choi J; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Hall CB; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Clouston SAP; The Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Cleven KL; Department of Family, Population and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
  • Mann FD; Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Luft BJ; Department of Family, Population and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
  • Zammit AR; World Trade Center Program Clinical Center of Excellence, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York, USA.
Am J Ind Med ; 67(9): 823-833, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38943489
ABSTRACT

BACKGROUND:

Posttraumatic stress disorder (PTSD) symptomatology and poorer pulmonary function are highly prevalent psychiatric and medical conditions. In the present study, we tested for the individual, additive, and modifying associations of PTSD symptomatology and pulmonary function with cognitive performance.

METHODS:

In this cross-sectional study, a total of 1,401 World Trade Center (WTC) responders (mean age = 53, SD = 8 years, 92% males) participated in the study. Cogstate assessment measured cognitive performance. PTSD symptomatology was measured using the trauma-specific version of the posttraumatic stress disorder checklist (PCL-17) adapted for the WTC attacks. The 1-second forced expiratory volume and forced vital capacity (FEV1/FVC) ratio was used to measure pulmonary function. Linear regressions with cognitive performance as the outcome were conducted to assess individual, additive, and moderating associations of PTSD symptomatology and pulmonary function.

RESULTS:

Higher PTSD symptomatology and poorer pulmonary function were negatively associated with cognitive performance. A 10% increase on the FEV1/FVC ratio moderated the association between PTSD symptomatology and cognition, whereby its association with cognition was stronger when PTSD symptomatology was higher (est. = 0.01, 95%CI = 0.004, 0.01, p < 0.001). When stratified by responder type, these associations persisted in trained (est. = 0.01, 95%CI = 0.01, 0.02, p < 0.001), but not in non-trained (est. = 0.004, 95% C.I. = -0.01, 0.02, p = 0.39) responders.

CONCLUSIONS:

In the presence of higher PTSD, better pulmonary functioning is associated with better cognitive performance. Early intervention efforts to mitigate preventable cognitive decline in high-risk populations should be studied, especially since intervention in one modality may have an impact on others.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Cognición / Ataques Terroristas del 11 de Septiembre Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Ind Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Cognición / Ataques Terroristas del 11 de Septiembre Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Ind Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos