Review of clinical and laboratory experiences with molindone hydrochloride.
J Clin Psychiatry
; 46(8 Pt 2): 30-3, 1985 Aug.
Article
en En
| MEDLINE
| ID: mdl-3894340
The literature concerning the pharmacokinetics, pharmacodynamics, receptor physiology, and clinical use of molindone is reviewed. Unanswered questions about the drug are addressed. Although molindone is reputed to have a short half-life (1.5 hours), clinical observations report a prolonged effect from a once-daily dose. Early in treatment, some patients show intolerance due to akathisia or extrapyramidal symptoms. This may be withdrawal dyskinesia due to discontinuation of another drug or an early adverse effect of molindone. Different effects on dopamine receptors have been described, but the significance of these properties for the development of tardive dyskinesia remains unclear.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Indoles
/
Molindona
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
J Clin Psychiatry
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Estados Unidos