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Association of Antibodies to Helminth Defense Molecule 1 With Inflammation, Organomegaly, and Decreased Nutritional Status in Schistosomiasis Japonica.
Ruiz, Amanda E; Pond-Tor, Sunthorn; Stuart, Ronald; Acosta, Luz P; Coutinho, Hannah M; Leenstra, Tjalling; Fisher, Sydney; Fahey, Owen; McDonald, Emily A; Jiz, Mario A; Olveda, Remigio M; McGarvey, Stephen T; Friedman, Jennifer F; Wu, Hannah Wei; Kurtis, Jonathan D.
Afiliación
  • Ruiz AE; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • Pond-Tor S; Department of Pathology and Laboratory Medicine, Brown University Medical School, Providence, Rhode Island, USA.
  • Stuart R; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • Acosta LP; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • Coutinho HM; Department of Immunology, Research Institute of Tropical Medicine, Manila, the Philippines.
  • Leenstra T; Department of Immunology, Research Institute of Tropical Medicine, Manila, the Philippines.
  • Fisher S; Department of Immunology, Research Institute of Tropical Medicine, Manila, the Philippines.
  • Fahey O; Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • McDonald EA; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • Jiz MA; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • Olveda RM; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • McGarvey ST; Department of Pediatrics, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • Friedman JF; Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, Rhode Island, USA.
  • Wu HW; Department of Pathology and Laboratory Medicine, Brown University Medical School, Providence, Rhode Island, USA.
  • Kurtis JD; Department of Immunology, Research Institute of Tropical Medicine, Manila, the Philippines.
J Infect Dis ; 230(4): 1023-1032, 2024 Oct 16.
Article en En | MEDLINE | ID: mdl-38942608
ABSTRACT
Immunomodulation enhances parasite fitness by reducing inflammation-induced morbidity in the mammalian host, as well as by attenuating parasite-targeting immune responses. Using a whole-proteome differential screening method, we identified Schistosoma japonicum helminth defense molecule 1 (SjHDM-1) as a target of antibodies expressed by S. japonicum-resistant but not S. japonicum-susceptible individuals. In a longitudinal cohort study (n = 644) conducted in a S. japonicum-endemic region of the Philippines, antibody levels to SjHDM-1 did not predict resistance to reinfection but were associated with increased measures of inflammation. Individuals with high levels of anti-SjHDM-1 immunoglobulin G had higher levels of C-reactive protein than those with low anti-SjHDM-1. High anti-SjHDM-1 immunoglobulin G responses were also associated with reduced biomarkers of nutritional status (albumin), as well as decreased anthropometric measures of nutritional status (weight-for-age and height-for-age z scores) and increased measures of hepatomegaly. Our results suggest that anti-SjHDM-1 responses inhibit the immunomodulatory function of SjHDM-1, resulting in increased morbidity rates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquistosomiasis Japónica / Anticuerpos Antihelmínticos / Estado Nutricional / Inflamación Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquistosomiasis Japónica / Anticuerpos Antihelmínticos / Estado Nutricional / Inflamación Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos