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6-Shogaol alleviates high-fat diet induced hepatic steatosis through miR-3066-5p/Grem2 pathway.
Jiao, Wenya; Jiao, Yingshuai; Sang, Yaxin; Wang, Xianghong; Wang, Shuo.
Afiliación
  • Jiao W; College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China.
  • Jiao Y; College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China.
  • Sang Y; College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China.
  • Wang X; College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China. Electronic address: wangshipin2017@163.com.
  • Wang S; Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. Electronic address: wangshuo@nankai.edu.cn.
Food Chem ; 457: 140197, 2024 Nov 01.
Article en En | MEDLINE | ID: mdl-38941907
ABSTRACT
The purpose of this study is to investigate the mechanism by which 6-shogaol ameliorates hepatic steatosis via miRNA-mRNA interaction analysis. C57BL/6 J mice were fed a high-fat diet (HFD) for 12 weeks, during which 6-shogaol was administered orally. The liver lipid level, liver function and oxidative damage in mice were evaluated. mRNA sequencing, miRNA sequencing, and RT-qPCR were employed to compare the expression profiles between the HFD group and the 6-shogaol-treated group. High-throughput sequencing was used to construct the mRNA and miRNA libraries. Target prediction and integration analysis identified eight potential miRNA-mRNA pairs involved in hepatic steatosis, which were subsequently validated in liver tissues and AML12 cells. The findings revealed that 6-shogaol modulates the miR-3066-5p/Grem2 pathway, thereby improving hepatic steatosis. This study provides new insights into the mechanisms through which 6-shogaol alleviates hepatic steatosis, establishing a foundation for future research on natural active compounds for the treatment of metabolic diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecoles / MicroARNs / Dieta Alta en Grasa / Ratones Endogámicos C57BL Límite: Animals / Humans / Male Idioma: En Revista: Food Chem Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catecoles / MicroARNs / Dieta Alta en Grasa / Ratones Endogámicos C57BL Límite: Animals / Humans / Male Idioma: En Revista: Food Chem Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido