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Python tooth-inspired fixation device for enhanced rotator cuff repair.
Kurtaliaj, Iden; Hoppe, Ethan D; Huang, Yuxuan; Ju, David; Sandler, Jacob A; Yoon, Donghwan; Smith, Lester J; Betancur, Silvio Torres; Effiong, Linda; Gardner, Thomas; Tedesco, Liana; Desai, Sohil; Birman, Victor; Levine, William N; Genin, Guy M; Thomopoulos, Stavros.
Afiliación
  • Kurtaliaj I; Department of Orthopaedic Surgery, Columbia University, New York, NY 10032, USA.
  • Hoppe ED; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
  • Huang Y; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Ju D; NSF Science and Technology Center for Engineering Mechanobiology, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Sandler JA; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Yoon D; NSF Science and Technology Center for Engineering Mechanobiology, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Smith LJ; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Betancur ST; NSF Science and Technology Center for Engineering Mechanobiology, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Effiong L; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Gardner T; NSF Science and Technology Center for Engineering Mechanobiology, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Tedesco L; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Desai S; NSF Science and Technology Center for Engineering Mechanobiology, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Birman V; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO 63130, USA.
  • Levine WN; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Genin GM; Department of Orthopaedic Surgery, Columbia University, New York, NY 10032, USA.
  • Thomopoulos S; Department of Orthopaedic Surgery, Columbia University, New York, NY 10032, USA.
Sci Adv ; 10(26): eadl5270, 2024 Jun 28.
Article en En | MEDLINE | ID: mdl-38941456
ABSTRACT
Rotator cuff repair surgeries fail frequently, with 20 to 94% of the 600,000 repairs performed annually in the United States resulting in retearing of the rotator cuff. The most common cause of failure is sutures tearing through tendons at grasping points. To address this issue, we drew inspiration from the specialized teeth of snakes of the Pythonoidea superfamily, which grasp soft tissues without tearing. To apply this nondamaging gripping approach to the surgical repair of tendon, we developed and optimized a python tooth-inspired device as an adjunct to current rotator cuff suture repair and found that it nearly doubled repair strength. Integrated simulations, 3D printing, and ex vivo experiments revealed a relationship between tooth shape and grasping mechanics, enabling optimization of the clinically relevant device that substantially enhances rotator cuff repair by distributing stresses over the attachment footprint. This approach suggests an alternative to traditional suturing paradigms and may reduce the risk of tendon retearing after rotator cuff repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manguito de los Rotadores / Boidae Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manguito de los Rotadores / Boidae Límite: Animals / Humans Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos