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Causal associations between psoriasis, eczema, urticaria, and mental illness: A bidirectional Mendelian randomization study of the European population.
Mo, Nian; Yang, Yujie; Wang, Wen; Zhou, Panyu; Liu, Fanlu; Zhang, Yating; Zhang, Junhong; Han, Ling; Lu, Chuanjian.
Afiliación
  • Mo N; The Second Clinical College of Guangzhou University of Chinese Medicine in Guangzhou, Guangzhou, China.
  • Yang Y; The Second Clinical College of Guangzhou University of Chinese Medicine in Guangzhou, Guangzhou, China.
  • Wang W; The Second Clinical College of Guangzhou University of Chinese Medicine in Guangzhou, Guangzhou, China.
  • Zhou P; The Second Clinical College of Guangzhou University of Chinese Medicine in Guangzhou, Guangzhou, China.
  • Liu F; The Second Clinical College of Guangzhou University of Chinese Medicine in Guangzhou, Guangzhou, China.
  • Zhang Y; Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan, China.
  • Zhang J; The Second Clinical College of Guangzhou University of Chinese Medicine in Guangzhou, Guangzhou, China.
  • Han L; The Second Clinical College of Guangzhou University of Chinese Medicine in Guangzhou, Guangzhou, China.
  • Lu C; State Key Laboratory of TCM Moisture Syndrome at the Second Affiliated Hospital of Guangzhou University of Chinese Medicine in Guangzhou, Guangzhou, China.
Medicine (Baltimore) ; 103(26): e38586, 2024 Jun 28.
Article en En | MEDLINE | ID: mdl-38941419
ABSTRACT
Observational studies have reported a relationship between multiple common dermatoses and mental illness. To assess the potential bidirectional causality between 3 skin disorders (psoriasis, eczema, and urticaria) and 4 psychiatric disorders (bipolar disorder, schizophrenia, major depressive disorder, and anxiety) in the European population, we used Mendelian randomization (MR) analysis, which provides definitive evidence for causal inference. Eligible single nucleotide polymorphisms were screened for dermatological and psychiatric disorders using a genome-wide association study database. We conducted bidirectional, 2-sample MR analysis using instrumental variables related to psoriasis, eczema, and urticaria as exposure factors, and bipolar disorder, schizophrenia, major depression, and anxiety as outcomes. Reverse MR analysis with bipolar disorder, schizophrenia, major depression, and anxiety as exposure and psoriasis, eczema, and urticaria as outcomes were also performed, and the causality was analyzed using inverse-variance weighting (IVW), MR-Egger, and weighted median methods. To thoroughly assess causality, sensitivity analyses were conducted using the IVW, MR-PRESSO, and MR-Egger methods. The results showed that bipolar disorder increased the incidence of psoriasis (odds ratio = 1.271, 95% confidence interval = 1.003-1.612, P = .047), heterogeneity test with Cochran Q test in the IVW showed P value > .05, (P = .302), the MR-Pleiotropy and MR-PRESSO (outlier methods) in the multiplicity test showed P value > .05, (P = .694; P = .441), and MR-Pleiotropy evidence showed no apparent intercept (intercept = -0.060; SE = 0.139; P = .694). Major depression increased the risk of eczema (odds ratio = 1.002, 95% confidence interval = 1.000-1.004, P = .024), heterogeneity test showed P value > .05, (P = .328), multiplicity detection showed P value > .05, (P = .572; P = .340), and MR-Pleiotropy evidence showed no apparent intercept (intercept = -0.099; SE = 0.162; P = .572). Sensitivity analyses of the above results were reliable, and no heterogeneity or multiplicity was found. This study demonstrated a statistically significant causality between bipolar disorder and psoriasis, major depression, and eczema in a European population, which could provide important information for physicians in the clinical management of common skin conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Polimorfismo de Nucleótido Simple / Eccema / Análisis de la Aleatorización Mendeliana Límite: Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Medicine (Baltimore) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Polimorfismo de Nucleótido Simple / Eccema / Análisis de la Aleatorización Mendeliana Límite: Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Medicine (Baltimore) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos