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Risk of peripheral neuropathy in patients with psoriasis and psoriatic arthritis. A prospective cohort study.
Doneddu, Pietro E; Borroni, Riccardo; Ceribelli, Angela; Carta, Francesca; Sechi, Margherita; Moretti, Giulia S; Giordano, Andrea; Scheveger, Francesco; Moret, Federica; Fernandes, Marco; Gentile, Francesco; Valenti, Mario; Luciano, Nicoletta; Bianchi, Elisa; Costanzo, Antonio; De Nittis, Pasquale E; Selmi, Carlo; Nobile-Orazio, Eduardo.
Afiliación
  • Doneddu PE; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Borroni R; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Ceribelli A; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Carta F; Dermatology Unit, Humanitas Research Hospital, IRCCS, Milan, Italy.
  • Sechi M; Division of Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Moretti GS; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Giordano A; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Scheveger F; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Moret F; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Fernandes M; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Gentile F; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Valenti M; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Luciano N; Neuromuscular and Neuroimmunology Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Bianchi E; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Costanzo A; Dermatology Unit, Humanitas Research Hospital, IRCCS, Milan, Italy.
  • De Nittis PE; Division of Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Selmi C; Laboratorio di Malattie Neurologiche, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
  • Nobile-Orazio E; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Muscle Nerve ; 70(3): 371-378, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38940240
ABSTRACT
INTRODUCTION/

AIMS:

Laboratory and clinical data suggest a link between neurologically mediated inflammation and psoriasis, but the risk and features of peripheral neuropathy in psoriasis or psoriatic arthritis remain unknown. The aim of this exploratory study was to evaluate the risk and to describe the features of peripheral neuropathy in patients with psoriasis and psoriatic arthritis.

METHODS:

One hundred patients with psoriasis and/or psoriatic arthritis and 100 control subjects were consecutively enrolled. Diagnostic confirmation included electrophysiological examination, skin biopsy, and nerve ultrasound for confirmed polyneuropathy.

RESULTS:

Nine patients were diagnosed with confirmed polyneuropathy, while none of the control subjects had the condition (relative risk [RR] = 19.00, 95% confidence interval [CI] = 1.12-322.11). Specific relative risks for polyneuropathy were 22.09 (95% CI = 1.17-416.43) in psoriasis patients and 18.75 (95% CI = 1.07-327.62) in psoriatic arthritis patients. The observed polyneuropathy in all nine patients was length-dependent, symmetrical, and predominantly sensory, with minimal or no disability. Comorbidities and exposure to therapies known to increase the risk of polyneuropathy were more frequent in psoriasis and/or psoriatic arthritis patients compared to controls (42% vs. 4%, p = .0001). Analyzing data after excluding possible contributory causes, the risk of polyneuropathy in patients with psoriasis and/or psoriatic arthritis was not significant.

DISCUSSION:

Psoriasis and psoriatic arthritis appear to be associated with an increased risk of polyneuropathy. This increased risk seems to be linked to the higher prevalence of contributing factors for polyneuropathy, rather than a direct increase in neuropathy risk specifically related to psoriasis and psoriatic arthritis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Artritis Psoriásica / Enfermedades del Sistema Nervioso Periférico Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psoriasis / Artritis Psoriásica / Enfermedades del Sistema Nervioso Periférico Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos