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Nosocomial outbreak caused by disinfectant-resistant Serratia marcescens in an adult intensive care unit, Hungary, February to March 2022.
Hanczvikkel, Adrienn; Tóth, Ákos; Kopcsóné Németh, Irén Anna; Bazsó, Orsolya; Závorszky, Lorinc; Buzgó, Lilla; Lesinszki, Virág; Göbhardter, Dániel; Ungvári, Erika; Damjanova, Ivelina; Eross, Attila; Hajdu, Ágnes.
Afiliación
  • Hanczvikkel A; ECDC Fellowship Programme, Public Health Microbiology path (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
  • Tóth Á; National Center for Public Health and Pharmacy (NNGYK), Budapest, Hungary.
  • Kopcsóné Németh IA; National Center for Public Health and Pharmacy (NNGYK), Budapest, Hungary.
  • Bazsó O; North-Pest Central Hospital - Military Hospital (ÉPC-HK), Budapest, Hungary.
  • Závorszky L; North-Pest Central Hospital - Military Hospital (ÉPC-HK), Budapest, Hungary.
  • Buzgó L; North-Pest Central Hospital - Military Hospital (ÉPC-HK), Budapest, Hungary.
  • Lesinszki V; National Center for Public Health and Pharmacy (NNGYK), Budapest, Hungary.
  • Göbhardter D; National Center for Public Health and Pharmacy (NNGYK), Budapest, Hungary.
  • Ungvári E; National Center for Public Health and Pharmacy (NNGYK), Budapest, Hungary.
  • Damjanova I; National Center for Public Health and Pharmacy (NNGYK), Budapest, Hungary.
  • Eross A; National Center for Public Health and Pharmacy (NNGYK), Budapest, Hungary.
  • Hajdu Á; North-Pest Central Hospital - Military Hospital (ÉPC-HK), Budapest, Hungary.
Euro Surveill ; 29(26)2024 Jun.
Article en En | MEDLINE | ID: mdl-38940004
ABSTRACT
In 2022, an outbreak with severe bloodstream infections caused by Serratia marcescens occurred in an adult intensive care unit (ICU) in Hungary. Eight cases, five of whom died, were detected. Initial control measures could not stop the outbreak. We conducted a matched case-control study. In univariable analysis, the cases were more likely to be located around one sink in the ICU and had more medical procedures and medications than the controls, however, the multivariable analysis was not conclusive. Isolates from blood cultures of the cases and the ICU environment were closely related by whole genome sequencing and resistant or tolerant against the quaternary ammonium compound surface disinfectant used in the ICU. Thus, S. marcescens was able to survive in the environment despite regular cleaning and disinfection. The hospital replaced the disinfectant with another one, tightened the cleaning protocol and strengthened hand hygiene compliance among the healthcare workers. Together, these control measures have proved effective to prevent new cases. Our results highlight the importance of multidisciplinary outbreak investigations, including environmental sampling, molecular typing and testing for disinfectant resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serratia marcescens / Infección Hospitalaria / Brotes de Enfermedades / Infecciones por Serratia / Desinfectantes / Unidades de Cuidados Intensivos Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Euro Surveill Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suecia
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serratia marcescens / Infección Hospitalaria / Brotes de Enfermedades / Infecciones por Serratia / Desinfectantes / Unidades de Cuidados Intensivos Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Euro Surveill Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suecia