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Antidiabetic, antidyslipidemia, and renoprotector potency of butterfly pea flower extract (Clitorea ternatea L.) in diabetes mellitus and dyslipidemia rats model.
Widowati, Wahyu; Darsono, Lusiana; Natariza, Maria R; Waluyo, Novaldo W; Gleyriena Tenda, Abigail M; Siahaan, Berlian H; Oktaviani, Reza; Zahiroh, Fadhilah Haifa; Utomo, Herry S; Rizal, Rizal.
Afiliación
  • Widowati W; Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
  • Darsono L; Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
  • Natariza MR; Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
  • Waluyo NW; Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
  • Gleyriena Tenda AM; Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
  • Siahaan BH; Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
  • Oktaviani R; Faculty of Medicine, Maranatha Christian University, Bandung, West Java 40164, Indonesia.
  • Zahiroh FH; Aretha Medika Utama Biomolecular and Biomedical Research Center, Bandung, West Java 40163, Indonesia.
  • Utomo HS; Louisiana State University (LSU) AgCenter, H. Rouse Caffey Rice Research Station, Rayne, LA 70578, USA.
  • Rizal R; Aretha Medika Utama Biomolecular and Biomedical Research Center, Bandung, West Java 40163, Indonesia.
Open Vet J ; 14(5): 1135-1145, 2024 May.
Article en En | MEDLINE | ID: mdl-38938424
ABSTRACT

Background:

Diabetes mellitus (DM) is a long-term condition marked by high blood glucose levels caused by insulin resistance which will lead to complications of other diseases such as dyslipidemia, which also affects the health of the liver and kidneys. Butterfly pea flower (Clitorea ternatea L.) has phenolic and flavonoid compounds which have the potential as herbal medicines for antidiabetics.

Aim:

The purpose of this study is to examine the potential of butterfly pea flower extract (BPE) as an antidiabetic, anti-dyslipidemia, and renoprotection.

Methods:

In vivo test was performed on Sprague Dawley rats (Rattus norvegicus L.) induced by Streptozotocin-Nicotinamide and High Fat Diet-Propylthiouracil as models of DM and dyslipidemia, and BPE was administered orally (200, 400, and 800 mg/kg BW) for 28 days. glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), tumor necrosis factor-α (TNF-α), nuclear factor-kappa beta (NF-kB), alkaline phosphatase (ALP), liver albumin levels, serum blood urea nitrogen (BUN), serum creatinine, and serum uric acid (UA), were measured by ELISA and colorimetry methods.

Results:

Treatment of BPE 800 mg/kg BW increased levels of GSH-Px, GST, albumin, and serum protein. BPE decreased TNF-α, NF-kB, and ALP. BPE also decreased BUN, serum CR, and serum UA.

Conclusion:

BPE has the potential to be used as a drug alternative for the treatment of DM and dyslipidemia as well as a hepatoprotective and renoprotective agent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Ratas Sprague-Dawley / Diabetes Mellitus Experimental / Dislipidemias / Hipoglucemiantes / Hipolipemiantes Límite: Animals Idioma: En Revista: Open Vet J Año: 2024 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Libia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Ratas Sprague-Dawley / Diabetes Mellitus Experimental / Dislipidemias / Hipoglucemiantes / Hipolipemiantes Límite: Animals Idioma: En Revista: Open Vet J Año: 2024 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Libia