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Borax attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/ROS balance in acrylamide-induced neurotoxicity in rainbow trout.
Turkez, Hasan; Alak, Gonca; Ozgeris, Fatma Betul; Cilingir Yeltekin, Asli; Ucar, Arzu; Parlak, Veysel; Sutan, Nicoleta Anca; Atamanalp, Muhammed.
Afiliación
  • Turkez H; Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
  • Alak G; Department of Seaafod Processing, Faculty of Fisheries, Atatürk University, Erzurum, Turkey.
  • Ozgeris FB; Department of Nutrition and Dietetics, Faculty of Health Sciences, Atatürk University, Erzurum, Turkey.
  • Cilingir Yeltekin A; Department of Chemistry, Faculty of Science, University of Yüzüncü Yil, Van, Turkey.
  • Ucar A; Department of Aquaculture, Faculty of Fisheries, Ataturk University, Erzurum, Turkey.
  • Parlak V; Department of Basic Sciences, Faculty of Fisheries, Ataturk University, Erzurum, Turkey.
  • Sutan NA; Department of Natural Sciences, University of Pitesti, Pitesti, Romania.
  • Atamanalp M; Department of Aquaculture, Faculty of Fisheries, Ataturk University, Erzurum, Turkey.
Drug Chem Toxicol ; : 1-10, 2024 Jun 28.
Article en En | MEDLINE | ID: mdl-38938109
ABSTRACT
Acrylamide (ACR) can have adverse environmental effects because of its multiple applications. Relevant scientific literatures of the existence of ACR residues in foods following processing steps have raised concern in the biochemistry, chemistry and safety of this vinyl substance. The interest has focused on the hepatotoxicity of ACR in animals and humans and on the ACR content mitigation and its detoxification. Borax (BX), as a naturally occurring antioxidant featured boron compound, was selected in this investigation to assess its possible neuro-protective potential against ACR-induced neurotoxicity. Nrf2 axis signaling pathways and detoxification response to oxidative stress after exposure to ACR in brains of rainbow trout, and the effect of BX application on reducing ACR-induced neurotoxicity were investigated. Rainbow trout were acutely exposed to ACR (12.5 mg/L) alone or simultaneously treated with BX (0.75 mg/L) during 96h. The exposed fish were sampled at 48th and 96th and oxidative stress response endpoints, 8-OHdG, Nrf2, TNF-α, caspase-3, in addition to IL-6 activities and the levels of AChE and BDNF in brain tissues of rainbow trout (Oncorhynchus mykiss) were evaluated. Samples showed decreases in the levels of ACR-mediated biomarkers used to assess neural toxicity (SOD, CAT, GPx, AChE, BDNF, GSH), increased levels of MDA, MPO, DNA damage and apoptosis. ACR disrupted the Nrf2 pathway, and induced neurotoxicity. Inhibited activities' expressions under simultaneous administration experiments, revealed the protective effects of BX against ACR-induced toxicity damage. The obtained data allow the outline of early multi-parameter signaling pathways in rainbow trout.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Drug Chem Toxicol Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Drug Chem Toxicol Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos