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Symmetry in Frontal But Not Motor and Somatosensory Cortical Projections.
Papale, Andrew E; Harish, Madhumita; Paletzki, Ronald F; O'Connor, Nathan J; Eastwood, Brian S; Seal, Rebecca P; Williamson, Ross S; Gerfen, Charles R; Hooks, Bryan M.
Afiliación
  • Papale AE; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 hooksm@pitt.edu gerfenc@mail.nih.gov papalea@pitt.edu.
  • Harish M; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
  • Paletzki RF; Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892.
  • O'Connor NJ; MBF Bioscience, Williston, Vermont 05495.
  • Eastwood BS; MBF Bioscience, Williston, Vermont 05495.
  • Seal RP; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
  • Williamson RS; Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
  • Gerfen CR; Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 hooksm@pitt.edu gerfenc@mail.nih.gov papalea@pitt.edu.
  • Hooks BM; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 hooksm@pitt.edu gerfenc@mail.nih.gov papalea@pitt.edu.
J Neurosci ; 44(33)2024 Aug 14.
Article en En | MEDLINE | ID: mdl-38937102
ABSTRACT
The neocortex and striatum are topographically organized for sensory and motor functions. While sensory and motor areas are lateralized for touch and motor control, respectively, frontal areas are involved in decision-making, where lateralization of function may be less important. This study contrasted the topographic precision of cell-type-specific ipsilateral and contralateral cortical projections while varying the injection site location in transgenic mice of both sexes. While sensory cortical areas had strongly topographic outputs to the ipsilateral cortex and striatum, they were weaker and not as topographically precise to contralateral targets. The motor cortex had somewhat stronger projections but still relatively weak contralateral topography. In contrast, frontal cortical areas had high degrees of topographic similarity for both ipsilateral and contralateral projections to the cortex and striatum. Corticothalamic organization is mainly ipsilateral, with weaker, more medial contralateral projections. Corticostriatal computations might integrate input outside closed basal ganglia loops using contralateral projections, enabling the two hemispheres to act as a unit to converge on one result in motor planning and decision-making.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Somatosensorial / Ratones Transgénicos / Lóbulo Frontal / Corteza Motora / Vías Nerviosas Límite: Animals Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Somatosensorial / Ratones Transgénicos / Lóbulo Frontal / Corteza Motora / Vías Nerviosas Límite: Animals Idioma: En Revista: J Neurosci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos