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Association of Clinicopathological Factors With MMP13 (rs2252070) Gene Polymorphism in Swedish Patients With Colorectal Cancer.
VAN Nguyen, Song; Shamoun, Levar; Landerholm, Kalle; Wågsäter, Dick; Dimberg, Jan.
Afiliación
  • VAN Nguyen S; Department of Medical Laboratory, Danang University of Medical Technology and Pharmacy, Danang, Vietnam.
  • Shamoun L; Department of Laboratory Medicine and Pathology, Region Jönköping County, Jönköping, Sweden; Levar.Shamoun@rjl.se.
  • Landerholm K; Department of Surgery, Region Jönköping County, Jönköping, Sweden.
  • Wågsäter D; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
  • Dimberg J; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
In Vivo ; 38(4): 1775-1782, 2024.
Article en En | MEDLINE | ID: mdl-38936942
ABSTRACT
BACKGROUND/

AIM:

Matrix metalloproteinase 13 (MMP13) has been reported to be involved in tumor development and progression, including of colorectal cancer (CRC). This study aimed at evaluating whether the MMP13 rs2252070 gene polymorphism is associated with clinicopathological factors and its influence on long-term survival in Swedish patients with CRC. PATIENTS AND

METHODS:

A total of 723 patients with CRC were genotyped using TaqMan single nucleotide polymorphism assays based on polymerase chain reaction.

RESULTS:

Assessing clinicopathological factors, we demonstrated that having the G/G genotype for MMP13 rs2252070 was significantly associated with poor differentiation, higher serum level of carcinoembryonic antigen and higher lymph node status. Moreover, the presence of a G allele was significantly related to larger tumor size in rectal cancer but had a significantly protective role against mucinous cancer, perineural invasion and lymphovascular invasion. Kaplan-Meier analysis showed no difference between genotypes regarding cancer-specific survival.

CONCLUSION:

Our findings highlight the potential of MMP13 rs2252070 polymorphism as a useful predictor of poor differentiation, serum level of carcinoembryonic antigen, lymph node status, tumor size, mucinous cancer, perineural invasion and lymphovascular invasion in patients with CRC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Polimorfismo de Nucleótido Simple / Metaloproteinasa 13 de la Matriz / Genotipo Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Polimorfismo de Nucleótido Simple / Metaloproteinasa 13 de la Matriz / Genotipo Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Grecia