Lethality associated with snake venom exposure can be predicted by temperature drop in Swiss mice.
Toxicon
; 247: 107831, 2024 Aug 28.
Article
en En
| MEDLINE
| ID: mdl-38936670
ABSTRACT
Establishing humane endpoints to minimize animal suffering in studies on snake venom toxicity and antivenom potency tests is crucial. Our findings reveal that Swiss mice exhibit early temperature drop following exposure to different snake venoms and combinations of venoms and antivenoms, predicting later mortality. Evaluating temperature we can identify within 3 h post-inoculation, the animals that will not survive in a period of 48 h. Implementing temperature as a criterion would significantly reduce animal suffering in these studies without compromising the outcomes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Venenos de Serpiente
/
Antivenenos
Límite:
Animals
Idioma:
En
Revista:
Toxicon
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Reino Unido