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The Posterior Insular Cortex is Necessary for Feeding-Induced Jejunal Myoelectrical Activity in Male Rats.
Shiratori, Reina; Yokoi, Taiki; Kinoshita, Kosuke; Xue, Wenfeng; Sasaki, Takuya; Kuga, Nahoko.
Afiliación
  • Shiratori R; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan.
  • Yokoi T; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan.
  • Kinoshita K; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan.
  • Xue W; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan.
  • Sasaki T; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan; Department of Neuropharmacology, Tohoku University School of Medicine, 4-1 Seiryo-machi, Aoba-Ku, Sendai 980-8575, Japan. Electronic address: takuya.sasaki.b4
  • Kuga N; Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan. Electronic address: nahoko.sasaki.a3@tohoku.ac.jp.
Neuroscience ; 553: 40-47, 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-38936460
ABSTRACT
The gastrointestinal tract exhibits coordinated muscle motility in response to food digestion, which is regulated by the central nervous system through autonomic control. The insular cortex is one of the brain regions that may regulate the muscle motility. In this study, we examined whether, and how, the insular cortex, especially the posterior part, regulates gastrointestinal motility by recording jejunal myoelectrical signals in response to feeding in freely moving male rats. Feeding was found to induce increases in jejunal myoelectrical signal amplitudes. This increase in the jejunal myoelectrical signals was abolished by vagotomy and pharmacological inhibition of the posterior insular cortex. Additionally, feeding induced a decrease and increase in sympathetic and parasympathetic nervous activities, respectively, both of which were eliminated by posterior insular cortical inhibition. These results suggest that the posterior insular cortex regulates jejunal motility in response to feeding by modulating autonomic tone.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Motilidad Gastrointestinal / Corteza Insular / Yeyuno Límite: Animals Idioma: En Revista: Neuroscience Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Motilidad Gastrointestinal / Corteza Insular / Yeyuno Límite: Animals Idioma: En Revista: Neuroscience Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos