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Pichia kudriavzevii (Candida krusei): A systematic review to inform the World Health Organisation priority list of fungal pathogens.
Nguyen, Thi Anh; Kim, Hannah Yejin; Stocker, Sophie; Kidd, Sarah; Alastruey-Izquierdo, Ana; Dao, Aiken; Harrison, Thomas; Wahyuningsih, Retno; Rickerts, Volker; Perfect, John; Denning, David W; Nucci, Marcio; Cassini, Alessandro; Beardsley, Justin; Gigante, Valeria; Sati, Hatim; Morrissey, C Orla; Alffenaar, Jan-Willem.
Afiliación
  • Nguyen TA; Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
  • Kim HY; Sydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia.
  • Stocker S; Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
  • Kidd S; Sydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia.
  • Alastruey-Izquierdo A; Department of Pharmacy, Westmead Hospital, Sydney, NSW, Australia.
  • Dao A; Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia.
  • Harrison T; Sydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia.
  • Wahyuningsih R; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, NSW, Australia.
  • Rickerts V; National Mycology Reference Centre, Microbiology and Infectious Diseases, SA Pathology, Adelaide, SA, Australia.
  • Perfect J; Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
  • Denning DW; Sydney Infectious Diseases Institute, The University of Sydney, Sydney, NSW, Australia.
  • Nucci M; Westmead Institute for Medical Research, Sydney, NSW, Australia.
  • Cassini A; Institute of Infection and Immunity, St George's University London, London, UK.
  • Beardsley J; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK.
  • Gigante V; Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Jakarta, Indonesia.
  • Sati H; Robert Koch Institute, Berlin, Germany.
  • Morrissey CO; Division of Infectious Diseases and International Health, Duke University School of Medicine, Durham, NC, USA.
  • Alffenaar JW; Manchester Fungal Infection Group (MFIG), Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Med Mycol ; 62(6)2024 Jun 27.
Article en En | MEDLINE | ID: mdl-38935911
ABSTRACT
In response to the growing global threat of fungal infections, in 2020 the World Health Organisation (WHO) established an Expert Group to identify priority fungi and develop the first WHO fungal priority pathogen list (FPPL). The aim of this systematic review was to evaluate the features and global impact of invasive infections caused by Pichia kudriavzevii (formerly known as Candida krusei). PubMed and Web of Science were used to identify studies published between 1 January 2011 and 18 February 2021 reporting on the criteria of mortality, morbidity (defined as hospitalisation and length of stay), drug resistance, preventability, yearly incidence, and distribution/emergence. Overall, 33 studies were evaluated. Mortality rates of up to 67% in adults were reported. Despite the intrinsic resistance of P. kudriavzevii to fluconazole with decreased susceptibility to amphotericin B, resistance (or non-wild-type rate) to other azoles and echinocandins was low, ranging between 0 and 5%. Risk factors for developing P. kudriavzevii infections included low birth weight, prior use of antibiotics/antifungals, and an underlying diagnosis of gastrointestinal disease or cancer. The incidence of infections caused by P. kudriavzevii is generally low (∼5% of all Candida-like blood isolates) and stable over the 10-year timeframe, although additional surveillance data are needed. Strategies targeting the identified risk factors for developing P. kudriavzevii infections should be developed and tested for effectiveness and feasibility of implementation. Studies presenting data on epidemiology and susceptibility of P. kudriavzevii were scarce, especially in low- and middle-income countries (LMICs). Thus, global surveillance systems are required to monitor the incidence, susceptibility, and morbidity of P. kudriavzevii invasive infections to inform diagnosis and treatment. Timely species-level identification and susceptibility testing should be conducted to reduce the high mortality and limit the spread of P. kudriavzevii in healthcare facilities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pichia / Organización Mundial de la Salud / Farmacorresistencia Fúngica / Antifúngicos Límite: Humans Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pichia / Organización Mundial de la Salud / Farmacorresistencia Fúngica / Antifúngicos Límite: Humans Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido