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Effects of cognitive behavioural therapy and exposure-response prevention on brain activation in obsessive-compulsive disorder patients: systematic review and meta-analysis.
Stephenson, Callum; Philipp-Muller, Aaron; Moghimi, Elnaz; Nashed, Joseph Y; Cook, Douglas J; Shirazi, Amirhossein; Milev, Roumen; Alavi, Nazanin.
Afiliación
  • Stephenson C; Queen's University, Kingston, Canada. cstephenson1212@gmail.com.
  • Philipp-Muller A; Queen's University, Kingston, Canada.
  • Moghimi E; Queen's University, Kingston, Canada.
  • Nashed JY; Queen's University, Kingston, Canada.
  • Cook DJ; Queen's University, Kingston, Canada.
  • Shirazi A; Queen's University, Kingston, Canada.
  • Milev R; Queen's University, Kingston, Canada.
  • Alavi N; Queen's University, Kingston, Canada.
Eur Arch Psychiatry Clin Neurosci ; 2024 Jun 27.
Article en En | MEDLINE | ID: mdl-38935215
ABSTRACT
Current psychotherapeutic treatments for OCD, while effective, have complex outcomes with mixed efficacy. Previous research has observed baseline brain activation patterns in OCD patients, elucidating some of the implications of this disorder. Observing the effects of evidence-based psychotherapeutics for OCD on brain activation (through MRI) may provide a more comprehensive outline of pathology. This systematic review and meta-analysis evaluated the effects of cognitive behavioural therapy (CBT) with exposure-response prevention (ERP) on brain activation in OCD patients. Academic databases were systematically searched, and the outcomes evaluated included changes in brain activation and symptom severity between baseline and post-treatment. Patients (n = 193) had confirmed OCD diagnosis and underwent protocolized CBT with ERP programs delivered by trained therapists. Participants in the CBT with ERP programs demonstrated significant improvements in symptom severity (Cohen's d = - 1.91). In general, CBT with ERP resulted in decreased activation post-treatment in the frontal (Cohen's d = 0.40), parietal (Cohen's d = 0.79), temporal (Cohen's d = 1.02), and occipital lobe (Cohen's d = 0.76), and cerebellum (Cohen's d = - 0.78). The findings support CBT with ERP's ability to improve brain activation abnormalities in OCD patients. By identifying regions that improved activation levels, psychotherapy programs may benefit from the addition of function-specific features that could improve treatment outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur Arch Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania