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Effects of Active Chronic Cigarette-Smoke Exposure on Circulating Fibrocytes.
Khan, Faheem; Judge, Eoin P; Das, Jeeban P; White, Daniel; Ingram, Carolyn; Keane, Michael P; Butler, Marcus W.
Afiliación
  • Khan F; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
  • Judge EP; University College Dublin, Belfield, Dublin 4, Ireland.
  • Das JP; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
  • White D; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
  • Ingram C; University College Dublin, Belfield, Dublin 4, Ireland.
  • Keane MP; University College Dublin, Belfield, Dublin 4, Ireland.
  • Butler MW; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Lung ; 202(4): 431-440, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38935158
ABSTRACT

PURPOSE:

This study aimed to evaluate the hypothesis that active smoking impacts upon mediators and abundance of circulating fibrocyte cells in smoking-related disease characterised by fibrosis.

METHODS:

Flow cytometry and enzyme-linked immunosorbent assays were used to investigate blood from five patient groups healthy never-smokers, healthy current smokers, stable chronic obstructive pulmonary disease (COPD) active smokers, idiopathic pulmonary fibrosis (IPF) never-smokers, and IPF active smokers.

RESULTS:

A significant inverse dose-response relationship was observed in healthy smokers among cumulative smoking burden (pack-years) and fibrocyte abundance (p = 0.006, r = -0.86). Among serum profibrotic fibrocyte chemokines measured, CCL18 rose significantly alongside fibrocyte numbers in all five subject groups, while having an inverse dose-response relationship with pack-year burden in healthy smokers (p = 0.003, r = -0.89). In IPF, CCL2 rose in direct proportion to fibrocyte abundance irrespective of smoking status but had lower serum levels in those currently smoking (p = < 0.001). For the study population, CXCL12 was decreased in pooled current smokers versus never-smokers (p = 0.03).

CONCLUSION:

The suppressive effect of current, as distinct from former, chronic smoking on circulating fibrocyte abundance in healthy smokers, and modulation of regulatory chemokine levels by active smoking may have implications for future studies of fibrocytes in smoking-related lung diseases as a potential confounding variable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimiocina CCL2 / Quimiocinas CC / Enfermedad Pulmonar Obstructiva Crónica / Quimiocina CXCL12 / Fibrosis Pulmonar Idiopática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lung Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimiocina CCL2 / Quimiocinas CC / Enfermedad Pulmonar Obstructiva Crónica / Quimiocina CXCL12 / Fibrosis Pulmonar Idiopática Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lung Año: 2024 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos