Your browser doesn't support javascript.
loading
Association of T-cell receptor repertoires and arterial stiffness in patients with essential hypertension.
Ma, Xiaoxiang; Zhuo, Yue; Zhang, Zhixin; Yang, Yanhua; He, Pengming; Zeng, Yi; Huang, Yan; Wen, Xueping.
Afiliación
  • Ma X; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China.
  • Zhuo Y; Department of Laboratory Research, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China.
  • Zhang Z; Chengdu ExAb Biotechnology LTD, Chengdu, China.
  • Yang Y; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China.
  • He P; Chengdu ExAb Biotechnology LTD, Chengdu, China.
  • Zeng Y; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China.
  • Huang Y; Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China.
  • Wen X; Chengdu ExAb Biotechnology LTD, Chengdu, China.
J Hypertens ; 42(8): 1440-1448, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-38934191
ABSTRACT

BACKGROUND:

Abnormal immune responses, particularly T-cell activity, are linked to vascular complications in hypertension, but mechanisms remain unknown. Our study aims to explore the association between arterial stiffness, assessed by brachial-ankle pulse wave velocity (baPWV), and T-cell receptor (TCR) repertoires in essential hypertension patients, focusing on understanding the role of T cells in the development of arterial stiffness in this population.

METHODS:

The study included 301 essential hypertension patients and 48 age-matched normotensive controls. Essential hypertension patients were stratified into high (baPWV ≥1400 cm/s, n = 213) and low (baPWV <1400 cm/s, n = 88) baPWV groups. High-throughput sequencing analyzed peripheral TCRß repertoires.

RESULTS:

Significant TCRß repertoire differences were observed between essential hypertension and normotensive groups, as well as between high and low baPWV essential hypertension subgroups. Specifically, patients in the high baPWV group exhibited notable variations in the utilization of specific TCR beta joining (TRBJ) and variable (TRBV) genes compared to the low baPWV group. These alterations were accompanied by reduced TCRß diversity (represented by diversity 50 s), increased percentages of the largest TCRß clones, and a higher number of TCRß clones exceeding 0.1%. The presence of specific TCRß clones was detected in both groups. Furthermore, reduced diversity 50s and elevated percentages of the largest TCRß clones were independently correlated with baPWV, emerging as potential risk factors for increased baPWV in essential hypertension patients.

CONCLUSION:

TCR repertoires were independently associated with arterial stiffness in patients with essential hypertension, implicating a potential role for dysregulated T-cell responses in the pathogenesis of arterial stiffness in this patient population.Trial registration ChiCTR2100054414.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rigidez Vascular / Hipertensión Esencial Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Hypertens Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rigidez Vascular / Hipertensión Esencial Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Hypertens Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos