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Projections of Endovascular Therapy-Eligible Patients With Stroke for the US Population.
Mistry, Eva A; Khoury, Jane C; Kleindorfer, Dawn O; Kissela, Brett M; Alwell, Kathleen S; Jasne, Adam S; Ferioli, Simona; De Los Rios La Rosa, Felipe; Coleman, Elisheva; Demel, Stacie L; Walsh, Kyle B; Slavin, Sabreena J; Star, Michael; Haverbusch, Mary; Mackey, Jason; Woo, Daniel; Aziz, Yasmin N; Heldner, Mirjam R; Fischer, Urs; Jadhav, Ashutosh P; Jovin, Tudor G; Albers, Gregory W; Nogueira, Raul G; Khatri, Pooja.
Afiliación
  • Mistry EA; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
  • Khoury JC; Division of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati Medical Center, OH (J.C.K.).
  • Kleindorfer DO; Department of Neurology, University of Michigan, Ann Arbor (D.O.K.).
  • Kissela BM; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
  • Alwell KS; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
  • Jasne AS; Department of Neurology, Yale University, New Haven, CT (A.S.J.).
  • Ferioli S; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
  • De Los Rios La Rosa F; Miami Neuroscience Institute, Baptist Health South Florida (F.D.L.R.L.R.).
  • Coleman E; Department of Neurology, University of Chicago, IL (E.C.).
  • Demel SL; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
  • Walsh KB; Department of Emergency Medicine (K.B.W.), University of Cincinnati, OH.
  • Slavin SJ; Department of Neurology, University of Kansas Medical Center (S.J.S.).
  • Star M; Department of Neurology, Soroka Medical Center, Beersheva, Israel (M.S.).
  • Haverbusch M; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
  • Mackey J; Department of Neurology, Indiana University School of Medicine, Indianapolis (J.M.).
  • Woo D; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
  • Aziz YN; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
  • Heldner MR; Stroke Research Center Bern, University Hospital Bern and University of Bern, Switzerland (M.R.H.).
  • Fischer U; Department of Neurology, University Hospital Basel and University of Basel, Switzerland (U.F.).
  • Jadhav AP; Barrow Neurological Institute, Phoenix, AZ (A.P.J.).
  • Jovin TG; Department of Neurology, Cooper University, Camden, NJ (T.G.J.).
  • Albers GW; Department of Neurology, Stanford University, CA (G.W.A.).
  • Nogueira RG; Department of Neurology, University of Pittsburgh, PA (R.G.N.).
  • Khatri P; Department of Neurology and Rehabilitation Medicine (E.A.M., B.M.K., K.S.A., S.F., S.L.D., M.H., D.W., Y.N.A., P.K.), University of Cincinnati, OH.
Stroke ; 55(8): 2011-2019, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38934124
ABSTRACT

BACKGROUND:

As stroke endovascular thrombectomy (EVT) treatment indications expand, understanding population-based EVT eligibility becomes critical for resource planning. We aimed to project current and future population-based EVT eligibility in the United States.

METHODS:

We conducted a post hoc analysis of the physician-adjudicated GCNKSS (Greater Cincinnati Northern Kentucky Stroke Study; 2015 epoch), a population-based, cross sectional, observational study of stroke incidence, treatment, and outcomes across a 5-county region. All hospitalized patients ≥18 years of age with acute ischemic stroke were ascertained using the International Classification of Diseases, Ninth Revision codes 430-436 and Tenth Revision codes I60-I67 and G45-G46 and extrapolated to the US adult census 2020. We determined the rate of EVT eligibility within the GCNKSS population using time from last known well to presentation (0-5 versus 5-23 hours), presenting National Institutes of Health Stroke Scale, and prestroke modified Rankin Scale. Both conservative and liberal estimates of prevalence of large vessel occlusion and large core were then applied based on literature review (unavailable within the 2015 GCNKSS). This eligibility was then extrapolated to the 2020 US population.

RESULTS:

Of the 1 057 183 adults within GCNKSS in 2015, 2741 had an ischemic stroke and 2176 had data available for analysis. We calculated that 8659 to 17 219 patients (conservative to liberal) meet the current guideline-recommended EVT criteria (nonlarge core, no prestroke disability, and National Institutes of Health Stroke Scale score ≥6) in the United States. Estimates (conservative to liberal) for expanded EVT eligibility subpopulations include (1) 5316 to 10 635 by large core; (2) 10 635 to 21 270 by mild presenting deficits with low National Institutes of Health Stroke Scale score; (3) 13 572 to 27 089 by higher prestroke disability; and (4) 7039 to 14 180 by >1 criteria. These expanded eligibility subpopulations amount to 36 562 to 73 174 patients.

CONCLUSIONS:

An estimated 8659 to 17 219 adult patients in the United States met strict EVT eligibility criteria in 2020. A 4-fold increase in population-based EVT eligibility can be anticipated with incremental adoption of recent or future positive trials. US stroke systems need to be rapidly optimized to handle all EVT-eligible patients with stroke.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombectomía / Accidente Cerebrovascular / Procedimientos Endovasculares Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Stroke Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombectomía / Accidente Cerebrovascular / Procedimientos Endovasculares Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Stroke Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos