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Clinical Validation of Carotid-Femoral Pulse Wave Velocity Measurement Using a Multi-Beam Laser Vibrometer: The CARDIS Study.
Badhwar, Smriti; Marais, Louise; Khettab, Hakim; Poli, Federica; Li, Yanlu; Segers, Patrick; Aasmul, Soren; de Melis, Mirko; Baets, Roel; Greenwald, Steve; Bruno, Rosa Maria; Boutouyrie, Pierre.
Afiliación
  • Badhwar S; Paris Cardiovascular Research Center (PARCC) Institut National de la Santé Et de la Researche Médicale (INSERM), Paris, France (S.B., L.M., F.P., R.M.B., P.B.).
  • Marais L; Paris Cardiovascular Research Center (PARCC) Institut National de la Santé Et de la Researche Médicale (INSERM), Paris, France (S.B., L.M., F.P., R.M.B., P.B.).
  • Khettab H; Hôpital européen Georges-Pompidou (HEGP), Assistance publique-Hôpitaux de Paris (APHP), Paris, France (H.K., R.M.B, P.B.).
  • Poli F; Paris Cardiovascular Research Center (PARCC) Institut National de la Santé Et de la Researche Médicale (INSERM), Paris, France (S.B., L.M., F.P., R.M.B., P.B.).
  • Li Y; Photonics Research Group, Ghent University-imec, Belgium (Y.L., R.B.).
  • Segers P; Center for Nano- and Biophotonics, Ghent University, Belgium (Y.L., R.B.).
  • Aasmul S; IBiTech- BioMMedA, Ghent University, Belgium (P.S.).
  • de Melis M; Medtronic Bakken Research Center, Maastricht, The Netherlands (S.A., M.d.M.).
  • Baets R; Medtronic Bakken Research Center, Maastricht, The Netherlands (S.A., M.d.M.).
  • Greenwald S; Photonics Research Group, Ghent University-imec, Belgium (Y.L., R.B.).
  • Bruno RM; Center for Nano- and Biophotonics, Ghent University, Belgium (Y.L., R.B.).
  • Boutouyrie P; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.G.).
Hypertension ; 81(9): 1986-1995, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38934112
ABSTRACT

BACKGROUND:

Carotid-femoral pulse wave velocity (cfPWV) is the gold standard for noninvasive arterial stiffness assessment, an independent predictor of cardiovascular disease, and a potential parameter to guide therapy. However, cfPWV is not routinely measured in clinical practice due to the unavailability of a low-cost, operator-friendly, and independent device. The current study validated a novel laser Doppler vibrometry (LDV)-based measurement of cfPWV against the reference technique.

METHODS:

In 100 (50 men) hypertensive patients, cfPWV was measured using applanation tonometry (Sphygmocor) and the novel LDV device. This device has 2 handpieces with 6 laser beams each that simultaneously measure vibrations from the skin surface at carotid and femoral sites. Pulse wave velocity is calculated using ECG for the identification of cardiac cycles. An ECG-independent method was also devised. Cardiovascular risk score was calculated for patients between 40 and 75 years old using the WHO risk scoring chart.

RESULTS:

LDV-based cfPWV correlated significantly with tonometry (r=0.86, P<0.0001 ECG-dependent [cfPWVLDV_ECG] and r=0.80, P<0.001 ECG-independent [cfPWVLDV_w/oECG] methods). Bland-Altman analysis showed nonsignificant bias (0.65 m/s) and acceptable SD (1.27 m/s) between methods. Intraobserver coefficient of variance for LDV was 4.7% (95% CI, 3.0%-5.5%), and interobserver coefficient of variance was 5.87%. CfPWV correlated significantly with CVD risk (r=0.64, P<0.001; r=0.41, P=0.003; and r=0.37, P=0.006 for tonometry, LDV-with, and LDV-without ECG, respectively).

CONCLUSIONS:

The study demonstrates clinical validity of the LDV device. The LDV provides a simple, noninvasive, operator-independent method to measure cfPWV for assessing arterial stiffness, comparable to the standard existing techniques. REGISTRATION URL https//clinicaltrials.gov/study/NCT03446430; Unique identifier NCT03446430.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rigidez Vascular / Velocidad de la Onda del Pulso Carotídeo-Femoral Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertension Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rigidez Vascular / Velocidad de la Onda del Pulso Carotídeo-Femoral Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hypertension Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos